Dtwd2 protein (mouse) - STRING interaction network

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Score

Dtwd2

DTW domain-containing protein 2. (298 aa)

Predicted Functional Partners:

Dtwd1

0.797

Tsr3

0.777

Dus2

0.681

Spink14

0.604

Msl1

0.594

Dus4l

0.585

Eipr1

0.535

Zfp474

0.517

Ocrl

0.487

Brix1

0.486

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brix1	Dtwd2	ENSMUSP00000022855	ENSMUSP00000128219	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	DTW domain-containing protein 2.	0.486
Brix1	Dus2	ENSMUSP00000022855	ENSMUSP00000034375	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	0.631
Brix1	Eipr1	ENSMUSP00000022855	ENSMUSP00000152220	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex.	0.593
Dtwd1	Dtwd2	ENSMUSP00000127662	ENSMUSP00000128219	DTW domain-containing protein 1.	DTW domain-containing protein 2.	0.797
Dtwd1	Dus2	ENSMUSP00000127662	ENSMUSP00000034375	DTW domain-containing protein 1.	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	0.653
Dtwd1	Dus4l	ENSMUSP00000127662	ENSMUSP00000020977	DTW domain-containing protein 1.	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus4 subfamily.	0.622
Dtwd1	Tsr3	ENSMUSP00000127662	ENSMUSP00000068511	DTW domain-containing protein 1.	Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.	0.782
Dtwd2	Brix1	ENSMUSP00000128219	ENSMUSP00000022855	DTW domain-containing protein 2.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.486
Dtwd2	Dtwd1	ENSMUSP00000128219	ENSMUSP00000127662	DTW domain-containing protein 2.	DTW domain-containing protein 1.	0.797
Dtwd2	Dus2	ENSMUSP00000128219	ENSMUSP00000034375	DTW domain-containing protein 2.	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	0.681
Dtwd2	Dus4l	ENSMUSP00000128219	ENSMUSP00000020977	DTW domain-containing protein 2.	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus4 subfamily.	0.585
Dtwd2	Eipr1	ENSMUSP00000128219	ENSMUSP00000152220	DTW domain-containing protein 2.	EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex.	0.535
Dtwd2	Msl1	ENSMUSP00000128219	ENSMUSP00000042792	DTW domain-containing protein 2.	Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). In the MSL complex, acts as a scaffold to [...]	0.594
Dtwd2	Ocrl	ENSMUSP00000128219	ENSMUSP00000001202	DTW domain-containing protein 2.	Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...]	0.487
Dtwd2	Spink14	ENSMUSP00000128219	ENSMUSP00000057781	DTW domain-containing protein 2.	Serine peptidase inhibitor, Kazal type 14.	0.604
Dtwd2	Tsr3	ENSMUSP00000128219	ENSMUSP00000068511	DTW domain-containing protein 2.	Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.	0.777
Dtwd2	Zfp474	ENSMUSP00000128219	ENSMUSP00000147873	DTW domain-containing protein 2.	Zinc finger protein 474.	0.517
Dus2	Brix1	ENSMUSP00000034375	ENSMUSP00000022855	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.	0.631
Dus2	Dtwd1	ENSMUSP00000034375	ENSMUSP00000127662	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	DTW domain-containing protein 1.	0.653
Dus2	Dtwd2	ENSMUSP00000034375	ENSMUSP00000128219	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily.	DTW domain-containing protein 2.	0.681