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Zp1 protein (mouse) - STRING interaction network
"Zp1" - Zona pellucida glycoprotein 1 in Mus musculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Zp1Zona pellucida glycoprotein 1; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (623 aa)    
Predicted Functional Partners:
Zp3
Zona pellucida glycoprotein 3; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation (424 aa)
     
 
  0.992
Zp2
Zona pellucida glycoprotein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (713 aa)
     
 
0.942
Adam2
A disintegrin and metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity) (735 aa)
     
 
  0.935
Ovgp1
Oviductal glycoprotein 1; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development (721 aa)
     
 
  0.920
Adam30
A disintegrin and metallopeptidase domain 30 (732 aa)
     
 
    0.901
Adam21
A disintegrin and metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients (729 aa)
     
 
    0.901
B4galt1
UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (399 aa)
         
    0.900
Zp3r
Zona pellucida 3 receptor; Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction (579 aa)
     
   
  0.610
Gdf9
Growth differentiation factor 9; Required for ovarian folliculogenesis (441 aa)
     
   
  0.574
Figla
Folliculogenesis specific basic helix-loop-helix; Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian develo [...] (194 aa)
           
  0.541
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mice, mouse, nude mice, transgenic mice
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