node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agt | Pga5 | ENSMUSP00000066488 | ENSMUSP00000025647 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.427 |
Cblif | Gkn1 | ENSMUSP00000025585 | ENSMUSP00000032129 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Belongs to the eukaryotic cobalamin transport proteins family. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.501 |
Cblif | Pga5 | ENSMUSP00000025585 | ENSMUSP00000025647 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Belongs to the eukaryotic cobalamin transport proteins family. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.439 |
Cpa2 | Pga5 | ENSMUSP00000093771 | ENSMUSP00000025647 | Carboxypeptidase A2. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.402 |
F5 | Pga5 | ENSMUSP00000083204 | ENSMUSP00000025647 | Coagulation factor V heavy chain; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin; Belongs to the multicopper oxidase family. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.561 |
Gkn1 | Cblif | ENSMUSP00000032129 | ENSMUSP00000025585 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Belongs to the eukaryotic cobalamin transport proteins family. | 0.501 |
Gkn1 | Gkn2 | ENSMUSP00000032129 | ENSMUSP00000032128 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Gastrokine-2. | 0.793 |
Gkn1 | Pga5 | ENSMUSP00000032129 | ENSMUSP00000025647 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.418 |
Gkn2 | Gkn1 | ENSMUSP00000032128 | ENSMUSP00000032129 | Gastrokine-2. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.793 |
Gkn2 | Pga5 | ENSMUSP00000032128 | ENSMUSP00000025647 | Gastrokine-2. | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | 0.529 |
Pga5 | Agt | ENSMUSP00000025647 | ENSMUSP00000066488 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.427 |
Pga5 | Cblif | ENSMUSP00000025647 | ENSMUSP00000025585 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Belongs to the eukaryotic cobalamin transport proteins family. | 0.439 |
Pga5 | Cpa2 | ENSMUSP00000025647 | ENSMUSP00000093771 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Carboxypeptidase A2. | 0.402 |
Pga5 | F5 | ENSMUSP00000025647 | ENSMUSP00000083204 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Coagulation factor V heavy chain; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin; Belongs to the multicopper oxidase family. | 0.561 |
Pga5 | Gkn1 | ENSMUSP00000025647 | ENSMUSP00000032129 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.418 |
Pga5 | Gkn2 | ENSMUSP00000025647 | ENSMUSP00000032128 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family. | Gastrokine-2. | 0.529 |