node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aasdh | Slc25a45 | ENSMUSP00000113792 | ENSMUSP00000025732 | Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an as yet unknown acceptor via an amide bond. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. | Solute carrier family 25 member 45. | 0.486 |
Cdc42ep2 | Dpf2 | ENSMUSP00000059883 | ENSMUSP00000113465 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | 0.456 |
Cdc42ep2 | Fam89b | ENSMUSP00000059883 | ENSMUSP00000097538 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the FAM89 family. | 0.522 |
Cdc42ep2 | Frmd8 | ENSMUSP00000059883 | ENSMUSP00000025728 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17- mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). | 0.442 |
Cdc42ep2 | Slc25a45 | ENSMUSP00000059883 | ENSMUSP00000025732 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | Solute carrier family 25 member 45. | 0.595 |
Cdc42ep2 | Tigd3 | ENSMUSP00000059883 | ENSMUSP00000157880 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | Tigger transposable element-derived protein 3. | 0.493 |
Cdc42ep2 | Znrd2 | ENSMUSP00000059883 | ENSMUSP00000025885 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | Protein ZNRD2; Might play a role in mitosis. Could be a centromere- associated protein. Antigenic molecule. May induce anti-centromere antibodies. | 0.477 |
Dpf2 | Cdc42ep2 | ENSMUSP00000113465 | ENSMUSP00000059883 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | 0.456 |
Dpf2 | Ehbp1l1 | ENSMUSP00000113465 | ENSMUSP00000037656 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | 0.442 |
Dpf2 | Fam89b | ENSMUSP00000113465 | ENSMUSP00000097538 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the FAM89 family. | 0.433 |
Dpf2 | Frmd8 | ENSMUSP00000113465 | ENSMUSP00000025728 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17- mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). | 0.477 |
Dpf2 | Slc25a45 | ENSMUSP00000113465 | ENSMUSP00000025732 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | Solute carrier family 25 member 45. | 0.503 |
Dpf2 | Tigd3 | ENSMUSP00000113465 | ENSMUSP00000157880 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | Tigger transposable element-derived protein 3. | 0.570 |
Dpf2 | Znrd2 | ENSMUSP00000113465 | ENSMUSP00000025885 | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | Protein ZNRD2; Might play a role in mitosis. Could be a centromere- associated protein. Antigenic molecule. May induce anti-centromere antibodies. | 0.560 |
Ehbp1l1 | Dpf2 | ENSMUSP00000037656 | ENSMUSP00000113465 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity). | 0.442 |
Ehbp1l1 | Fam89b | ENSMUSP00000037656 | ENSMUSP00000097538 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the FAM89 family. | 0.546 |
Ehbp1l1 | Frmd8 | ENSMUSP00000037656 | ENSMUSP00000025728 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17- mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). | 0.595 |
Ehbp1l1 | Slc25a45 | ENSMUSP00000037656 | ENSMUSP00000025732 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | Solute carrier family 25 member 45. | 0.587 |
Ehbp1l1 | Tigd3 | ENSMUSP00000037656 | ENSMUSP00000157880 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. | Tigger transposable element-derived protein 3. | 0.693 |
Fam89b | Cdc42ep2 | ENSMUSP00000097538 | ENSMUSP00000059883 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the FAM89 family. | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family. | 0.522 |