Cbwd1 protein (mouse) - STRING interaction network

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Score

Cbwd1

COBW domain-containing protein 1. (393 aa)

Predicted Functional Partners:

Metap1

0.862

Rps29

0.639

Rsad1

0.634

Mrps14

0.633

Tcerg1

0.618

Mrpl33

0.612

Fam72a

0.598

Efl1

0.505

Kank1

0.504

Eed

0.488

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cbwd1	Eed	ENSMUSP00000025815	ENSMUSP00000102853	COBW domain-containing protein 1.	Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...]	0.488
Cbwd1	Efl1	ENSMUSP00000025815	ENSMUSP00000046046	COBW domain-containing protein 1.	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	0.505
Cbwd1	Fam72a	ENSMUSP00000025815	ENSMUSP00000068111	COBW domain-containing protein 1.	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity); Belongs to the FAM72 family.	0.598
Cbwd1	Kank1	ENSMUSP00000025815	ENSMUSP00000042177	COBW domain-containing protein 1.	KN motif and ankyrin repeat domains 1.	0.504
Cbwd1	Metap1	ENSMUSP00000025815	ENSMUSP00000029804	COBW domain-containing protein 1.	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.862
Cbwd1	Mrpl33	ENSMUSP00000025815	ENSMUSP00000031024	COBW domain-containing protein 1.	39S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family.	0.612
Cbwd1	Mrps14	ENSMUSP00000025815	ENSMUSP00000120075	COBW domain-containing protein 1.	28S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family.	0.633
Cbwd1	Rps29	ENSMUSP00000025815	ENSMUSP00000038352	COBW domain-containing protein 1.	40S ribosomal protein S29.	0.639
Cbwd1	Rsad1	ENSMUSP00000025815	ENSMUSP00000037361	COBW domain-containing protein 1.	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl- L-methionine (By similarity).	0.634
Cbwd1	Tcerg1	ENSMUSP00000025815	ENSMUSP00000158288	COBW domain-containing protein 1.	Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity).	0.618
Eed	Cbwd1	ENSMUSP00000102853	ENSMUSP00000025815	Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...]	COBW domain-containing protein 1.	0.488
Efl1	Cbwd1	ENSMUSP00000046046	ENSMUSP00000025815	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	COBW domain-containing protein 1.	0.505
Efl1	Metap1	ENSMUSP00000046046	ENSMUSP00000029804	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.543
Efl1	Mrpl33	ENSMUSP00000046046	ENSMUSP00000031024	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	39S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family.	0.609
Efl1	Mrps14	ENSMUSP00000046046	ENSMUSP00000120075	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	28S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family.	0.681
Efl1	Rps29	ENSMUSP00000046046	ENSMUSP00000038352	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	40S ribosomal protein S29.	0.681
Efl1	Rsad1	ENSMUSP00000046046	ENSMUSP00000037361	Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...]	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl- L-methionine (By similarity).	0.681
Fam72a	Cbwd1	ENSMUSP00000068111	ENSMUSP00000025815	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity); Belongs to the FAM72 family.	COBW domain-containing protein 1.	0.598
Kank1	Cbwd1	ENSMUSP00000042177	ENSMUSP00000025815	KN motif and ankyrin repeat domains 1.	COBW domain-containing protein 1.	0.504
Metap1	Cbwd1	ENSMUSP00000029804	ENSMUSP00000025815	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	COBW domain-containing protein 1.	0.862