node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gtpbp4 | Nmd3 | ENSMUSP00000152412 | ENSMUSP00000029358 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 0.994 |
Gtpbp4 | Nop53 | ENSMUSP00000152412 | ENSMUSP00000043981 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.998 |
Gtpbp4 | Pa2g4 | ENSMUSP00000152412 | ENSMUSP00000114434 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1- regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved [...] | 0.990 |
Gtpbp4 | Rpl11 | ENSMUSP00000152412 | ENSMUSP00000099595 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.875 |
Gtpbp4 | Rpl19 | ENSMUSP00000152412 | ENSMUSP00000017548 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L19. | 0.930 |
Gtpbp4 | Rpl23 | ENSMUSP00000152412 | ENSMUSP00000099435 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L23. | 0.906 |
Gtpbp4 | Rpl23a | ENSMUSP00000152412 | ENSMUSP00000099541 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.975 |
Gtpbp4 | Rpl4 | ENSMUSP00000152412 | ENSMUSP00000034966 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.955 |
Gtpbp4 | Rpl5 | ENSMUSP00000152412 | ENSMUSP00000080854 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.954 |
Gtpbp4 | Rpl8 | ENSMUSP00000152412 | ENSMUSP00000155657 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. | 0.899 |
Nmd3 | Gtpbp4 | ENSMUSP00000029358 | ENSMUSP00000152412 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.994 |
Nmd3 | Nop53 | ENSMUSP00000029358 | ENSMUSP00000043981 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.761 |
Nmd3 | Pa2g4 | ENSMUSP00000029358 | ENSMUSP00000114434 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1- regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved [...] | 0.995 |
Nmd3 | Rpl11 | ENSMUSP00000029358 | ENSMUSP00000099595 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.924 |
Nmd3 | Rpl19 | ENSMUSP00000029358 | ENSMUSP00000017548 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L19. | 0.853 |
Nmd3 | Rpl23 | ENSMUSP00000029358 | ENSMUSP00000099435 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L23. | 0.891 |
Nmd3 | Rpl23a | ENSMUSP00000029358 | ENSMUSP00000099541 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.961 |
Nmd3 | Rpl4 | ENSMUSP00000029358 | ENSMUSP00000034966 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.884 |
Nmd3 | Rpl5 | ENSMUSP00000029358 | ENSMUSP00000080854 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.963 |
Nmd3 | Rpl8 | ENSMUSP00000029358 | ENSMUSP00000155657 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. | 60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family. | 0.921 |