node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adam2 | Adam7 | ENSMUSP00000022618 | ENSMUSP00000022640 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | 0.552 |
Adam2 | Crisp1 | ENSMUSP00000022618 | ENSMUSP00000026498 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | 0.562 |
Adam2 | Izumo1 | ENSMUSP00000022618 | ENSMUSP00000033100 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. | 0.679 |
Adam2 | Spam1 | ENSMUSP00000022618 | ENSMUSP00000143970 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. | 0.716 |
Adam2 | Zan | ENSMUSP00000022618 | ENSMUSP00000114068 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. | 0.772 |
Adam7 | Adam2 | ENSMUSP00000022640 | ENSMUSP00000022618 | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.552 |
Adam7 | Crisp1 | ENSMUSP00000022640 | ENSMUSP00000026498 | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | 0.546 |
Adam7 | Lcn5 | ENSMUSP00000022640 | ENSMUSP00000028306 | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | Epididymal-specific lipocalin-5, major form; Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation. Belongs to the calycin superfamily. Lipocalin family. | 0.679 |
Cdh1 | Crisp1 | ENSMUSP00000000312 | ENSMUSP00000026498 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers recep [...] | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | 0.544 |
Cdh1 | Crisp3 | ENSMUSP00000000312 | ENSMUSP00000026499 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers recep [...] | Cysteine-rich secretory protein 3; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens; Belongs to the CRISP family. | 0.540 |
Crisp1 | Adam2 | ENSMUSP00000026498 | ENSMUSP00000022618 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.562 |
Crisp1 | Adam7 | ENSMUSP00000026498 | ENSMUSP00000022640 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | 0.546 |
Crisp1 | Cdh1 | ENSMUSP00000026498 | ENSMUSP00000000312 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers recep [...] | 0.544 |
Crisp1 | Crisp3 | ENSMUSP00000026498 | ENSMUSP00000026499 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Cysteine-rich secretory protein 3; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens; Belongs to the CRISP family. | 0.576 |
Crisp1 | Izumo1 | ENSMUSP00000026498 | ENSMUSP00000033100 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. | 0.583 |
Crisp1 | Lcn5 | ENSMUSP00000026498 | ENSMUSP00000028306 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Epididymal-specific lipocalin-5, major form; Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation. Belongs to the calycin superfamily. Lipocalin family. | 0.597 |
Crisp1 | Plb1 | ENSMUSP00000026498 | ENSMUSP00000144040 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. | 0.673 |
Crisp1 | Spam1 | ENSMUSP00000026498 | ENSMUSP00000143970 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. | 0.560 |
Crisp1 | Spink8 | ENSMUSP00000026498 | ENSMUSP00000142586 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Serine protease inhibitor Kazal-type 8; Probable serine protease inhibitor. | 0.567 |
Crisp1 | Zan | ENSMUSP00000026498 | ENSMUSP00000114068 | Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens. | Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. | 0.548 |