node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr3 | Avil | ENSMUSP00000137503 | ENSMUSP00000026500 | Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | 0.582 |
Avil | Actr3 | ENSMUSP00000026500 | ENSMUSP00000137503 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] | 0.582 |
Avil | Cog3 | ENSMUSP00000026500 | ENSMUSP00000045016 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.487 |
Avil | Cog6 | ENSMUSP00000026500 | ENSMUSP00000048603 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.505 |
Avil | Cog8 | ENSMUSP00000026500 | ENSMUSP00000093173 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.532 |
Avil | Scarf1 | ENSMUSP00000026500 | ENSMUSP00000044248 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Scavenger receptor class F member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity). Plays a role in the regulation of neurite-like outgrowth. | 0.493 |
Avil | Scn10a | ENSMUSP00000026500 | ENSMUSP00000081845 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | 0.619 |
Avil | Scn9a | ENSMUSP00000026500 | ENSMUSP00000097642 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain ; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. | 0.537 |
Avil | Sh2d7 | ENSMUSP00000026500 | ENSMUSP00000053690 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | SH2 domain-containing protein 7. | 0.532 |
Avil | Svil | ENSMUSP00000026500 | ENSMUSP00000115078 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Supervillin; [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. | 0.617 |
Avil | Trpv1 | ENSMUSP00000026500 | ENSMUSP00000099585 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.496 |
Cog3 | Avil | ENSMUSP00000045016 | ENSMUSP00000026500 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | 0.487 |
Cog3 | Cog6 | ENSMUSP00000045016 | ENSMUSP00000048603 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.999 |
Cog3 | Cog8 | ENSMUSP00000045016 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
Cog6 | Avil | ENSMUSP00000048603 | ENSMUSP00000026500 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | 0.505 |
Cog6 | Cog3 | ENSMUSP00000048603 | ENSMUSP00000045016 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
Cog6 | Cog8 | ENSMUSP00000048603 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
Cog8 | Avil | ENSMUSP00000093173 | ENSMUSP00000026500 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family. | 0.532 |
Cog8 | Cog3 | ENSMUSP00000093173 | ENSMUSP00000045016 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
Cog8 | Cog6 | ENSMUSP00000093173 | ENSMUSP00000048603 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.999 |