STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates. (648 aa)    
Predicted Functional Partners:
Gns
N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.
  
 0.966
Kl
Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1; Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
    
 0.954
Ugt2a3
UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family.
     
 0.951
Ugt2b34
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.948
Ugt2b1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Ugt2b35
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Ugt2b37
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Ugt2b36
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Ugt1a5
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Ugt1a6b
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
 0.946
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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