STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem47Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin. (181 aa)    
Predicted Functional Partners:
Fam47c
Family with sequence similarity 47, member A.
      
 0.706
Itm2a
Integral membrane protein 2A; Belongs to the ITM2 family.
   
  
 0.587
Tmem178
Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.
   
  
 0.562
Tmem94
Transmembrane protein 94.
      
 0.537
Tmem183a
Transmembrane protein 183.
   
  
 0.507
Depdc7
DEP domain-containing protein 7.
      
 0.498
Rasl10b
Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small GTPase superfamily. Ras family.
   
  
 0.490
Gdap1l1
Ganglioside-induced differentiation-associated protein 1-like 1; Belongs to the GST superfamily.
   
  
 0.489
Cpxm1
Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet.
   
  
 0.478
Prrg1
Proline-rich Gla (G-carboxyglutamic acid) 1.
   
  
 0.471
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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