node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dctd | Dhfr | ENSMUSP00000126733 | ENSMUSP00000022218 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.530 |
Dctd | Dtymk | ENSMUSP00000126733 | ENSMUSP00000027503 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | 0.969 |
Dctd | Dut | ENSMUSP00000126733 | ENSMUSP00000080767 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxyuridine triphosphatase. | 0.976 |
Dctd | Tk1 | ENSMUSP00000126733 | ENSMUSP00000026661 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase, cytosolic. | 0.969 |
Dctd | Tyms | ENSMUSP00000126733 | ENSMUSP00000026846 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.980 |
Dhfr | Dctd | ENSMUSP00000022218 | ENSMUSP00000126733 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.530 |
Dhfr | Dtymk | ENSMUSP00000022218 | ENSMUSP00000027503 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | 0.653 |
Dhfr | Dut | ENSMUSP00000022218 | ENSMUSP00000080767 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Deoxyuridine triphosphatase. | 0.638 |
Dhfr | Mthfd1 | ENSMUSP00000022218 | ENSMUSP00000021443 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.984 |
Dhfr | Mthfd2 | ENSMUSP00000022218 | ENSMUSP00000005810 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.795 |
Dhfr | Mthfr | ENSMUSP00000022218 | ENSMUSP00000069774 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | 0.850 |
Dhfr | Shmt1 | ENSMUSP00000022218 | ENSMUSP00000018744 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.990 |
Dhfr | Shmt2 | ENSMUSP00000022218 | ENSMUSP00000026470 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.988 |
Dhfr | Tk1 | ENSMUSP00000022218 | ENSMUSP00000026661 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Thymidine kinase, cytosolic. | 0.819 |
Dhfr | Tyms | ENSMUSP00000022218 | ENSMUSP00000026846 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.999 |
Dtymk | Dctd | ENSMUSP00000027503 | ENSMUSP00000126733 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.969 |
Dtymk | Dhfr | ENSMUSP00000027503 | ENSMUSP00000022218 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.653 |
Dtymk | Dut | ENSMUSP00000027503 | ENSMUSP00000080767 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | Deoxyuridine triphosphatase. | 0.982 |
Dtymk | Mthfd1 | ENSMUSP00000027503 | ENSMUSP00000021443 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.467 |
Dtymk | Shmt1 | ENSMUSP00000027503 | ENSMUSP00000018744 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.447 |