node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd44 | Mars2 | ENSMUSP00000137616 | ENSMUSP00000049770 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.507 |
Ankrd44 | Rftn2 | ENSMUSP00000137616 | ENSMUSP00000027121 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.433 |
Arl6ip6 | N6amt1 | ENSMUSP00000028336 | ENSMUSP00000061835 | ADP-ribosylation factor-like protein 6-interacting protein 6. | Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] | 0.588 |
Arl6ip6 | Plbd2 | ENSMUSP00000028336 | ENSMUSP00000031597 | ADP-ribosylation factor-like protein 6-interacting protein 6. | Putative phospholipase B-like 2 15 kDa form; Putative phospholipase. | 0.582 |
Arl6ip6 | Rftn2 | ENSMUSP00000028336 | ENSMUSP00000027121 | ADP-ribosylation factor-like protein 6-interacting protein 6. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.618 |
Mars2 | Ankrd44 | ENSMUSP00000049770 | ENSMUSP00000137616 | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | 0.507 |
Mars2 | Rftn2 | ENSMUSP00000049770 | ENSMUSP00000027121 | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.515 |
Mospd2 | Rftn2 | ENSMUSP00000004715 | ENSMUSP00000027121 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.500 |
N6amt1 | Arl6ip6 | ENSMUSP00000061835 | ENSMUSP00000028336 | Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.588 |
N6amt1 | Plbd2 | ENSMUSP00000061835 | ENSMUSP00000031597 | Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] | Putative phospholipase B-like 2 15 kDa form; Putative phospholipase. | 0.515 |
N6amt1 | Rftn2 | ENSMUSP00000061835 | ENSMUSP00000027121 | Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.553 |
Nuggc | Rftn2 | ENSMUSP00000078434 | ENSMUSP00000027121 | Nuclear GTPase SLIP-GC; Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity). Reduces somatic hypermutation in B-cells which may enhance genome stability. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.493 |
Otop1 | Rftn2 | ENSMUSP00000109734 | ENSMUSP00000027121 | Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates [...] | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.458 |
Plbd2 | Arl6ip6 | ENSMUSP00000031597 | ENSMUSP00000028336 | Putative phospholipase B-like 2 15 kDa form; Putative phospholipase. | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.582 |
Plbd2 | N6amt1 | ENSMUSP00000031597 | ENSMUSP00000061835 | Putative phospholipase B-like 2 15 kDa form; Putative phospholipase. | Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] | 0.515 |
Plbd2 | Rftn2 | ENSMUSP00000031597 | ENSMUSP00000027121 | Putative phospholipase B-like 2 15 kDa form; Putative phospholipase. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.580 |
Plxdc2 | Rftn2 | ENSMUSP00000028081 | ENSMUSP00000027121 | Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family. | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | 0.470 |
Rftn2 | Ankrd44 | ENSMUSP00000027121 | ENSMUSP00000137616 | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | 0.433 |
Rftn2 | Arl6ip6 | ENSMUSP00000027121 | ENSMUSP00000028336 | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.618 |
Rftn2 | Mars2 | ENSMUSP00000027121 | ENSMUSP00000049770 | Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.515 |