node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acad9 | Coa5 | ENSMUSP00000011492 | ENSMUSP00000027286 | Complex I assembly factor ACAD9, mitochondrial; As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein. | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.705 |
Coa5 | Acad9 | ENSMUSP00000027286 | ENSMUSP00000011492 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Complex I assembly factor ACAD9, mitochondrial; As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein. | 0.705 |
Coa5 | Coa6 | ENSMUSP00000027286 | ENSMUSP00000058279 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.715 |
Coa5 | Cox14 | ENSMUSP00000027286 | ENSMUSP00000023761 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | 0.679 |
Coa5 | Cox17 | ENSMUSP00000027286 | ENSMUSP00000113430 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Cytochrome c oxidase assembly protein 17, copper chaperone. | 0.783 |
Coa5 | Cox19 | ENSMUSP00000027286 | ENSMUSP00000062046 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase. | 0.713 |
Coa5 | Gfer | ENSMUSP00000027286 | ENSMUSP00000049186 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | FAD-linked sulfhydryl oxidase ALR; FAD-dependent sulfhydryl oxidase that regenerates the redox- active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity). | 0.708 |
Coa5 | Gm21987 | ENSMUSP00000027286 | ENSMUSP00000112386 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.781 |
Coa5 | Mrpl51 | ENSMUSP00000027286 | ENSMUSP00000032485 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 39S ribosomal protein L51, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL51 family. | 0.717 |
Coa5 | Pet117 | ENSMUSP00000027286 | ENSMUSP00000139043 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Protein PET117 homolog, mitochondrial. | 0.781 |
Coa5 | Sco2 | ENSMUSP00000027286 | ENSMUSP00000155150 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | Protein SCO2 homolog, mitochondrial; Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. Belongs to the SCO1/2 family. | 0.694 |
Coa6 | Coa5 | ENSMUSP00000058279 | ENSMUSP00000027286 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.715 |
Coa6 | Cox14 | ENSMUSP00000058279 | ENSMUSP00000023761 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | 0.644 |
Coa6 | Cox17 | ENSMUSP00000058279 | ENSMUSP00000113430 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Cytochrome c oxidase assembly protein 17, copper chaperone. | 0.754 |
Coa6 | Cox19 | ENSMUSP00000058279 | ENSMUSP00000062046 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase. | 0.740 |
Coa6 | Gm21987 | ENSMUSP00000058279 | ENSMUSP00000112386 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.739 |
Coa6 | Pet117 | ENSMUSP00000058279 | ENSMUSP00000139043 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Protein PET117 homolog, mitochondrial. | 0.743 |
Coa6 | Sco2 | ENSMUSP00000058279 | ENSMUSP00000155150 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | Protein SCO2 homolog, mitochondrial; Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. Belongs to the SCO1/2 family. | 0.806 |
Cox14 | Coa5 | ENSMUSP00000023761 | ENSMUSP00000027286 | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.679 |
Cox14 | Coa6 | ENSMUSP00000023761 | ENSMUSP00000058279 | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.644 |