node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agxt | Amt | ENSMUSP00000027491 | ENSMUSP00000035230 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.963 |
Agxt | Gldc | ENSMUSP00000027491 | ENSMUSP00000025778 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.960 |
Agxt | Grhpr | ENSMUSP00000027491 | ENSMUSP00000047218 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity). | 0.988 |
Agxt | Hao1 | ENSMUSP00000027491 | ENSMUSP00000028704 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.984 |
Agxt | Hao2 | ENSMUSP00000027491 | ENSMUSP00000029464 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.967 |
Agxt | Hoga1 | ENSMUSP00000027491 | ENSMUSP00000080414 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline. | 0.979 |
Agxt | Pipox | ENSMUSP00000027491 | ENSMUSP00000017597 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.965 |
Agxt | Sds | ENSMUSP00000027491 | ENSMUSP00000143838 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | L-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family. | 0.966 |
Agxt | Shmt1 | ENSMUSP00000027491 | ENSMUSP00000018744 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.977 |
Agxt | Tha1 | ENSMUSP00000027491 | ENSMUSP00000033230 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | L-threonine aldolase. | 0.962 |
Amt | Agxt | ENSMUSP00000035230 | ENSMUSP00000027491 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 0.963 |
Amt | Gldc | ENSMUSP00000035230 | ENSMUSP00000025778 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.999 |
Amt | Hao1 | ENSMUSP00000035230 | ENSMUSP00000028704 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.414 |
Amt | Hao2 | ENSMUSP00000035230 | ENSMUSP00000029464 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.414 |
Amt | Pipox | ENSMUSP00000035230 | ENSMUSP00000017597 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.631 |
Amt | Shmt1 | ENSMUSP00000035230 | ENSMUSP00000018744 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.977 |
Amt | Tha1 | ENSMUSP00000035230 | ENSMUSP00000033230 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | L-threonine aldolase. | 0.418 |
Gldc | Agxt | ENSMUSP00000025778 | ENSMUSP00000027491 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 0.960 |
Gldc | Amt | ENSMUSP00000025778 | ENSMUSP00000035230 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.999 |
Gldc | Grhpr | ENSMUSP00000025778 | ENSMUSP00000047218 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity). | 0.540 |