node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cln3 | Cln5 | ENSMUSP00000081636 | ENSMUSP00000022721 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.974 |
Cln3 | Cln6 | ENSMUSP00000081636 | ENSMUSP00000034776 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Ceroid-lipofuscinosis, neuronal 6. | 0.929 |
Cln3 | Cln8 | ENSMUSP00000081636 | ENSMUSP00000027554 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. | 0.899 |
Cln3 | Ctsd | ENSMUSP00000081636 | ENSMUSP00000121203 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.692 |
Cln3 | Ctsf | ENSMUSP00000081636 | ENSMUSP00000112481 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. | 0.705 |
Cln3 | Dnajc5 | ENSMUSP00000081636 | ENSMUSP00000072175 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | DnaJ homolog subfamily C member 5; Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium- dependent neurotransmitter release at nerve endings (By similarity). | 0.626 |
Cln3 | Mfsd8 | ENSMUSP00000081636 | ENSMUSP00000026859 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | 0.881 |
Cln3 | Ppt1 | ENSMUSP00000081636 | ENSMUSP00000030412 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.928 |
Cln3 | Tpp1 | ENSMUSP00000081636 | ENSMUSP00000033184 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity). | 0.822 |
Cln5 | Cln3 | ENSMUSP00000022721 | ENSMUSP00000081636 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.974 |
Cln5 | Cln6 | ENSMUSP00000022721 | ENSMUSP00000034776 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Ceroid-lipofuscinosis, neuronal 6. | 0.955 |
Cln5 | Cln8 | ENSMUSP00000022721 | ENSMUSP00000027554 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. | 0.916 |
Cln5 | Ctsd | ENSMUSP00000022721 | ENSMUSP00000121203 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.687 |
Cln5 | Ctsf | ENSMUSP00000022721 | ENSMUSP00000112481 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. | 0.699 |
Cln5 | Dnajc5 | ENSMUSP00000022721 | ENSMUSP00000072175 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | DnaJ homolog subfamily C member 5; Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium- dependent neurotransmitter release at nerve endings (By similarity). | 0.577 |
Cln5 | Mfsd8 | ENSMUSP00000022721 | ENSMUSP00000026859 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | 0.881 |
Cln5 | Ppt1 | ENSMUSP00000022721 | ENSMUSP00000030412 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.913 |
Cln5 | Tpp1 | ENSMUSP00000022721 | ENSMUSP00000033184 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity). | 0.798 |
Cln6 | Cln3 | ENSMUSP00000034776 | ENSMUSP00000081636 | Ceroid-lipofuscinosis, neuronal 6. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.929 |
Cln6 | Cln5 | ENSMUSP00000034776 | ENSMUSP00000022721 | Ceroid-lipofuscinosis, neuronal 6. | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.955 |