node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Il10rb | Il19 | ENSMUSP00000023691 | ENSMUSP00000139406 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | 0.908 |
Il10rb | Il20 | ENSMUSP00000023691 | ENSMUSP00000027673 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3; Belongs to the IL-10 family. | 0.770 |
Il10rb | Il20ra | ENSMUSP00000023691 | ENSMUSP00000020185 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity). | 0.991 |
Il10rb | Il20rb | ENSMUSP00000023691 | ENSMUSP00000096057 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin 20 receptor beta. | 0.520 |
Il10rb | Il22 | ENSMUSP00000023691 | ENSMUSP00000094449 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo; Belongs to the IL-10 family. | 0.999 |
Il10rb | Il22ra1 | ENSMUSP00000023691 | ENSMUSP00000099605 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.999 |
Il10rb | Il24 | ENSMUSP00000023691 | ENSMUSP00000113064 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. | 0.889 |
Il19 | Il10rb | ENSMUSP00000139406 | ENSMUSP00000023691 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | 0.908 |
Il19 | Il20 | ENSMUSP00000139406 | ENSMUSP00000027673 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3; Belongs to the IL-10 family. | 0.923 |
Il19 | Il20ra | ENSMUSP00000139406 | ENSMUSP00000020185 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity). | 0.995 |
Il19 | Il20rb | ENSMUSP00000139406 | ENSMUSP00000096057 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin 20 receptor beta. | 0.991 |
Il19 | Il22 | ENSMUSP00000139406 | ENSMUSP00000094449 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo; Belongs to the IL-10 family. | 0.755 |
Il19 | Il22ra1 | ENSMUSP00000139406 | ENSMUSP00000099605 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.910 |
Il19 | Il22ra2 | ENSMUSP00000139406 | ENSMUSP00000042642 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-22 receptor subunit alpha-2; Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. | 0.770 |
Il19 | Il24 | ENSMUSP00000139406 | ENSMUSP00000113064 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. | 0.964 |
Il19 | Il2rg | ENSMUSP00000139406 | ENSMUSP00000033664 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). | 0.718 |
Il19 | Il6st | ENSMUSP00000139406 | ENSMUSP00000138836 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | Interleukin-6 receptor subunit beta; Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6 (By similarity). Essential for [...] | 0.686 |
Il20 | Il10rb | ENSMUSP00000027673 | ENSMUSP00000023691 | Interleukin-20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3; Belongs to the IL-10 family. | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | 0.770 |
Il20 | Il19 | ENSMUSP00000027673 | ENSMUSP00000139406 | Interleukin-20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3; Belongs to the IL-10 family. | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family. | 0.923 |
Il20 | Il20ra | ENSMUSP00000027673 | ENSMUSP00000020185 | Interleukin-20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3; Belongs to the IL-10 family. | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity). | 0.994 |