node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abcc2 | Fmo2 | ENSMUSP00000026208 | ENSMUSP00000044405 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family. | 0.497 |
Abcc2 | Fmo4 | ENSMUSP00000026208 | ENSMUSP00000107150 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | 0.414 |
Abcc2 | Fmo5 | ENSMUSP00000026208 | ENSMUSP00000102665 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. | 0.401 |
Abcc2 | Slc10a1 | ENSMUSP00000026208 | ENSMUSP00000151555 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. | 0.800 |
Actrt1 | Fmo4 | ENSMUSP00000062570 | ENSMUSP00000107150 | Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | 0.434 |
Actrt1 | Wscd2 | ENSMUSP00000062570 | ENSMUSP00000092021 | Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. | WSC domain-containing protein 2. | 0.551 |
Aldh3b3 | Cat | ENSMUSP00000136334 | ENSMUSP00000028610 | Aldehyde dehydrogenase family 3 member B3; Oxidizes medium and long chain aldehydes into non-toxic fatty acids. | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | 0.585 |
Aldh3b3 | Fmo4 | ENSMUSP00000136334 | ENSMUSP00000107150 | Aldehyde dehydrogenase family 3 member B3; Oxidizes medium and long chain aldehydes into non-toxic fatty acids. | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | 0.482 |
Cat | Aldh3b3 | ENSMUSP00000028610 | ENSMUSP00000136334 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Aldehyde dehydrogenase family 3 member B3; Oxidizes medium and long chain aldehydes into non-toxic fatty acids. | 0.585 |
Cat | Fmo4 | ENSMUSP00000028610 | ENSMUSP00000107150 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | 0.452 |
Cat | Hao2 | ENSMUSP00000028610 | ENSMUSP00000029464 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.921 |
Fmo2 | Abcc2 | ENSMUSP00000044405 | ENSMUSP00000026208 | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family. | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.497 |
Fmo2 | Fmo4 | ENSMUSP00000044405 | ENSMUSP00000107150 | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family. | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | 0.416 |
Fmo2 | Fmo5 | ENSMUSP00000044405 | ENSMUSP00000102665 | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family. | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. | 0.553 |
Fmo4 | Abcc2 | ENSMUSP00000107150 | ENSMUSP00000026208 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.414 |
Fmo4 | Actrt1 | ENSMUSP00000107150 | ENSMUSP00000062570 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. | 0.434 |
Fmo4 | Aldh3b3 | ENSMUSP00000107150 | ENSMUSP00000136334 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Aldehyde dehydrogenase family 3 member B3; Oxidizes medium and long chain aldehydes into non-toxic fatty acids. | 0.482 |
Fmo4 | Cat | ENSMUSP00000107150 | ENSMUSP00000028610 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | 0.452 |
Fmo4 | Fmo2 | ENSMUSP00000107150 | ENSMUSP00000044405 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family. | 0.416 |
Fmo4 | Fmo5 | ENSMUSP00000107150 | ENSMUSP00000102665 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family. | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. | 0.432 |