node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brix1 | Ddx18 | ENSMUSP00000022855 | ENSMUSP00000001724 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | 0.991 |
Brix1 | Ebna1bp2 | ENSMUSP00000022855 | ENSMUSP00000030501 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.999 |
Brix1 | Ftsj3 | ENSMUSP00000022855 | ENSMUSP00000021048 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | 0.950 |
Brix1 | Gtpbp4 | ENSMUSP00000022855 | ENSMUSP00000152412 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.997 |
Brix1 | Mrto4 | ENSMUSP00000022855 | ENSMUSP00000099561 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.990 |
Brix1 | Nifk | ENSMUSP00000022855 | ENSMUSP00000027626 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | MKI67 FHA domain-interacting nucleolar phosphoprotein. | 0.999 |
Brix1 | Noc2l | ENSMUSP00000022855 | ENSMUSP00000137253 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). | 0.993 |
Brix1 | Nsun6 | ENSMUSP00000022855 | ENSMUSP00000141924 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates. | 0.950 |
Brix1 | Rpf2 | ENSMUSP00000022855 | ENSMUSP00000138581 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.991 |
Brix1 | Rsl1d1 | ENSMUSP00000022855 | ENSMUSP00000113431 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. | 0.993 |
Ddx18 | Brix1 | ENSMUSP00000001724 | ENSMUSP00000022855 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | 0.991 |
Ddx18 | Ebna1bp2 | ENSMUSP00000001724 | ENSMUSP00000030501 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.982 |
Ddx18 | Ftsj3 | ENSMUSP00000001724 | ENSMUSP00000021048 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | 0.990 |
Ddx18 | Gtpbp4 | ENSMUSP00000001724 | ENSMUSP00000152412 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.997 |
Ddx18 | Mrto4 | ENSMUSP00000001724 | ENSMUSP00000099561 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.993 |
Ddx18 | Nifk | ENSMUSP00000001724 | ENSMUSP00000027626 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | MKI67 FHA domain-interacting nucleolar phosphoprotein. | 0.999 |
Ddx18 | Noc2l | ENSMUSP00000001724 | ENSMUSP00000137253 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). | 0.995 |
Ddx18 | Nsun6 | ENSMUSP00000001724 | ENSMUSP00000141924 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates. | 0.964 |
Ddx18 | Rpf2 | ENSMUSP00000001724 | ENSMUSP00000138581 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.989 |
Ddx18 | Rsl1d1 | ENSMUSP00000001724 | ENSMUSP00000113431 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. | 0.998 |