Prg3 protein (mouse) - STRING interaction network

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Score

Prg3

Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. (222 aa)

Predicted Functional Partners:

Epx

0.822

Prg2

0.781

Pappa

0.667

Ear6

0.536

Pappa2

0.472

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ear6	Epx	ENSMUSP00000127152	ENSMUSP00000050497	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	0.553
Ear6	Prg2	ENSMUSP00000127152	ENSMUSP00000028467	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	0.578
Ear6	Prg3	ENSMUSP00000127152	ENSMUSP00000028466	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	0.536
Epx	Ear6	ENSMUSP00000050497	ENSMUSP00000127152	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	0.553
Epx	Prg2	ENSMUSP00000050497	ENSMUSP00000028467	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	0.878
Epx	Prg3	ENSMUSP00000050497	ENSMUSP00000028466	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	0.822
Pappa	Prg2	ENSMUSP00000081545	ENSMUSP00000028467	Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	0.927
Pappa	Prg3	ENSMUSP00000081545	ENSMUSP00000028466	Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	0.667
Pappa2	Prg2	ENSMUSP00000124022	ENSMUSP00000028467	Pappalysin 2.	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	0.472
Pappa2	Prg3	ENSMUSP00000124022	ENSMUSP00000028466	Pappalysin 2.	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	0.472
Prg2	Ear6	ENSMUSP00000028467	ENSMUSP00000127152	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	0.578
Prg2	Epx	ENSMUSP00000028467	ENSMUSP00000050497	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	0.878
Prg2	Pappa	ENSMUSP00000028467	ENSMUSP00000081545	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.	0.927
Prg2	Pappa2	ENSMUSP00000028467	ENSMUSP00000124022	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	Pappalysin 2.	0.472
Prg2	Prg3	ENSMUSP00000028467	ENSMUSP00000028466	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	0.781
Prg3	Ear6	ENSMUSP00000028466	ENSMUSP00000127152	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family.	0.536
Prg3	Epx	ENSMUSP00000028466	ENSMUSP00000050497	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily.	0.822
Prg3	Pappa	ENSMUSP00000028466	ENSMUSP00000081545	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.	0.667
Prg3	Pappa2	ENSMUSP00000028466	ENSMUSP00000124022	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	Pappalysin 2.	0.472
Prg3	Prg2	ENSMUSP00000028466	ENSMUSP00000028467	Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.	Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity).	0.781