node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bard1 | Ola1 | ENSMUSP00000027393 | ENSMUSP00000028517 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. | 0.777 |
Farsb | Mars | ENSMUSP00000129828 | ENSMUSP00000130666 | Phenylalanine--tRNA ligase beta subunit. | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.720 |
Farsb | Ola1 | ENSMUSP00000129828 | ENSMUSP00000028517 | Phenylalanine--tRNA ligase beta subunit. | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. | 0.762 |
Farsb | Ptrh1 | ENSMUSP00000129828 | ENSMUSP00000068850 | Phenylalanine--tRNA ligase beta subunit. | Probable peptidyl-tRNA hydrolase. | 0.447 |
Farsb | Rars | ENSMUSP00000129828 | ENSMUSP00000018992 | Phenylalanine--tRNA ligase beta subunit. | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. | 0.804 |
Farsb | Rars2 | ENSMUSP00000129828 | ENSMUSP00000029968 | Phenylalanine--tRNA ligase beta subunit. | Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.740 |
Farsb | Rps5 | ENSMUSP00000129828 | ENSMUSP00000104179 | Phenylalanine--tRNA ligase beta subunit. | 40S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. | 0.614 |
Farsb | Yars | ENSMUSP00000129828 | ENSMUSP00000101669 | Phenylalanine--tRNA ligase beta subunit. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.957 |
Mars | Farsb | ENSMUSP00000130666 | ENSMUSP00000129828 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | Phenylalanine--tRNA ligase beta subunit. | 0.720 |
Mars | Ola1 | ENSMUSP00000130666 | ENSMUSP00000028517 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. | 0.723 |
Mars | Rars | ENSMUSP00000130666 | ENSMUSP00000018992 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. | 0.999 |
Mars | Rars2 | ENSMUSP00000130666 | ENSMUSP00000029968 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.986 |
Mars | Rps5 | ENSMUSP00000130666 | ENSMUSP00000104179 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | 40S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. | 0.499 |
Mars | Yars | ENSMUSP00000130666 | ENSMUSP00000101669 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
Mcts1 | Ola1 | ENSMUSP00000000365 | ENSMUSP00000028517 | Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. | 0.912 |
Mcts1 | Rps5 | ENSMUSP00000000365 | ENSMUSP00000104179 | Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] | 40S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family. | 0.847 |
Mrpl21 | Ola1 | ENSMUSP00000025745 | ENSMUSP00000028517 | 39S ribosomal protein L21, mitochondrial. | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. | 0.716 |
Mrpl21 | Ptrh1 | ENSMUSP00000025745 | ENSMUSP00000068850 | 39S ribosomal protein L21, mitochondrial. | Probable peptidyl-tRNA hydrolase. | 0.551 |
Mrpl21 | Rars | ENSMUSP00000025745 | ENSMUSP00000018992 | 39S ribosomal protein L21, mitochondrial. | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. | 0.709 |
Mrpl21 | Rars2 | ENSMUSP00000025745 | ENSMUSP00000029968 | 39S ribosomal protein L21, mitochondrial. | Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.679 |