| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Btbd1 | Dscc1 | ENSMUSP00000026093 | ENSMUSP00000023059 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | 0.526 |
| Btbd1 | Irf6 | ENSMUSP00000026093 | ENSMUSP00000075839 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | 0.457 |
| Btbd1 | Prrg4 | ENSMUSP00000026093 | ENSMUSP00000028593 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.526 |
| Ccdc73 | Prrg4 | ENSMUSP00000106743 | ENSMUSP00000028593 | Coiled-coil domain-containing protein 73. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.597 |
| Ccdc73 | Qser1 | ENSMUSP00000106743 | ENSMUSP00000114062 | Coiled-coil domain-containing protein 73. | Glutamine and serine-rich 1. | 0.611 |
| Ccdc73 | Tcp11l1 | ENSMUSP00000106743 | ENSMUSP00000106747 | Coiled-coil domain-containing protein 73. | T-complex protein 11-like protein 1; Belongs to the TCP11 family. | 0.681 |
| Cep41 | Prrg4 | ENSMUSP00000031810 | ENSMUSP00000028593 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.530 |
| Dscc1 | Btbd1 | ENSMUSP00000023059 | ENSMUSP00000026093 | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | 0.526 |
| Dscc1 | Irf6 | ENSMUSP00000023059 | ENSMUSP00000075839 | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | 0.464 |
| Dscc1 | Prrg4 | ENSMUSP00000023059 | ENSMUSP00000028593 | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.534 |
| Irf6 | Btbd1 | ENSMUSP00000075839 | ENSMUSP00000026093 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | 0.457 |
| Irf6 | Dscc1 | ENSMUSP00000075839 | ENSMUSP00000023059 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | 0.464 |
| Irf6 | Prrg4 | ENSMUSP00000075839 | ENSMUSP00000028593 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.524 |
| Nedd4 | Prrg4 | ENSMUSP00000034740 | ENSMUSP00000028593 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | 0.791 |
| Prrg4 | Btbd1 | ENSMUSP00000028593 | ENSMUSP00000026093 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis. | 0.526 |
| Prrg4 | Ccdc73 | ENSMUSP00000028593 | ENSMUSP00000106743 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | Coiled-coil domain-containing protein 73. | 0.597 |
| Prrg4 | Cep41 | ENSMUSP00000028593 | ENSMUSP00000031810 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | 0.530 |
| Prrg4 | Dscc1 | ENSMUSP00000028593 | ENSMUSP00000023059 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity). | 0.534 |
| Prrg4 | Irf6 | ENSMUSP00000028593 | ENSMUSP00000075839 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family. | 0.524 |
| Prrg4 | Nedd4 | ENSMUSP00000028593 | ENSMUSP00000034740 | Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity). | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] | 0.791 |
