node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyba | Duox1 | ENSMUSP00000017604 | ENSMUSP00000097060 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | Dual oxidase 1. | 0.975 |
Cyba | Duox2 | ENSMUSP00000017604 | ENSMUSP00000050314 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | Dual oxidase 2. | 0.942 |
Cyba | Duoxa2 | ENSMUSP00000017604 | ENSMUSP00000028656 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | Dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (By similarity). Belongs to the DUOXA family. | 0.632 |
Cyba | Nox1 | ENSMUSP00000017604 | ENSMUSP00000033610 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.999 |
Cyba | Nox3 | ENSMUSP00000017604 | ENSMUSP00000111466 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. | 0.999 |
Cyba | Noxa1 | ENSMUSP00000017604 | ENSMUSP00000037423 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. | 0.999 |
Cyba | Noxo1 | ENSMUSP00000017604 | ENSMUSP00000019464 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. | 0.999 |
Duox1 | Cyba | ENSMUSP00000097060 | ENSMUSP00000017604 | Dual oxidase 1. | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | 0.975 |
Duox1 | Duox2 | ENSMUSP00000097060 | ENSMUSP00000050314 | Dual oxidase 1. | Dual oxidase 2. | 0.921 |
Duox1 | Duoxa2 | ENSMUSP00000097060 | ENSMUSP00000028656 | Dual oxidase 1. | Dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (By similarity). Belongs to the DUOXA family. | 0.997 |
Duox1 | Iyd | ENSMUSP00000097060 | ENSMUSP00000019896 | Dual oxidase 1. | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). | 0.636 |
Duox1 | Nox1 | ENSMUSP00000097060 | ENSMUSP00000033610 | Dual oxidase 1. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.991 |
Duox1 | Nox3 | ENSMUSP00000097060 | ENSMUSP00000111466 | Dual oxidase 1. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. | 0.978 |
Duox1 | Noxa1 | ENSMUSP00000097060 | ENSMUSP00000037423 | Dual oxidase 1. | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. | 0.883 |
Duox1 | Noxo1 | ENSMUSP00000097060 | ENSMUSP00000019464 | Dual oxidase 1. | NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. | 0.894 |
Duox1 | Slc26a4 | ENSMUSP00000097060 | ENSMUSP00000001253 | Dual oxidase 1. | Pendrin; Sodium-independent transporter of chloride and iodide. | 0.593 |
Duox1 | Slc5a5 | ENSMUSP00000097060 | ENSMUSP00000000809 | Dual oxidase 1. | Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.613 |
Duox2 | Cyba | ENSMUSP00000050314 | ENSMUSP00000017604 | Dual oxidase 2. | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family. | 0.942 |
Duox2 | Duox1 | ENSMUSP00000050314 | ENSMUSP00000097060 | Dual oxidase 2. | Dual oxidase 1. | 0.921 |
Duox2 | Duoxa2 | ENSMUSP00000050314 | ENSMUSP00000028656 | Dual oxidase 2. | Dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (By similarity). Belongs to the DUOXA family. | 0.998 |