node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agxt | Dao | ENSMUSP00000027491 | ENSMUSP00000107911 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.957 |
Agxt | Grhpr | ENSMUSP00000027491 | ENSMUSP00000047218 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity). | 0.988 |
Agxt | Hao1 | ENSMUSP00000027491 | ENSMUSP00000028704 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.984 |
Agxt | Hao2 | ENSMUSP00000027491 | ENSMUSP00000029464 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.967 |
Agxt | Hoga1 | ENSMUSP00000027491 | ENSMUSP00000080414 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline. | 0.979 |
Amy1 | Amy2a1 | ENSMUSP00000070368 | ENSMUSP00000118962 | Alpha-amylase 1. | Alpha-amylase. | 0.907 |
Amy1 | Amy2a2 | ENSMUSP00000070368 | ENSMUSP00000096264 | Alpha-amylase 1. | Pancreatic alpha-amylase. | 0.908 |
Amy1 | Hao1 | ENSMUSP00000070368 | ENSMUSP00000028704 | Alpha-amylase 1. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.855 |
Amy2a1 | Amy1 | ENSMUSP00000118962 | ENSMUSP00000070368 | Alpha-amylase. | Alpha-amylase 1. | 0.907 |
Amy2a1 | Amy2a2 | ENSMUSP00000118962 | ENSMUSP00000096264 | Alpha-amylase. | Pancreatic alpha-amylase. | 0.908 |
Amy2a1 | Hao1 | ENSMUSP00000118962 | ENSMUSP00000028704 | Alpha-amylase. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.834 |
Amy2a2 | Amy1 | ENSMUSP00000096264 | ENSMUSP00000070368 | Pancreatic alpha-amylase. | Alpha-amylase 1. | 0.908 |
Amy2a2 | Amy2a1 | ENSMUSP00000096264 | ENSMUSP00000118962 | Pancreatic alpha-amylase. | Alpha-amylase. | 0.908 |
Amy2a2 | Hao1 | ENSMUSP00000096264 | ENSMUSP00000028704 | Pancreatic alpha-amylase. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.828 |
Cat | Hao1 | ENSMUSP00000028610 | ENSMUSP00000028704 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.924 |
Cat | Hao2 | ENSMUSP00000028610 | ENSMUSP00000029464 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.921 |
Dao | Agxt | ENSMUSP00000107911 | ENSMUSP00000027491 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 0.957 |
Dao | Grhpr | ENSMUSP00000107911 | ENSMUSP00000047218 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity). | 0.867 |
Dao | Hao1 | ENSMUSP00000107911 | ENSMUSP00000028704 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.885 |
Dao | Hao2 | ENSMUSP00000107911 | ENSMUSP00000029464 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.883 |