STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cst8Cystatin-8; Performs a specialized role during sperm development and maturation; Belongs to the cystatin family. (142 aa)    
Predicted Functional Partners:
Cstdc2
Cystatin domain-containing 2.
   
  
 0.839
Cst12
Cystatin-12; May play a specialized role in spermatogenesis.
   
  
 0.762
Cst9
Cystatin-9; May be involved in testis development. May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria.
   
  
0.689
Lcn8
Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
   
  
 0.602
Gzf1
GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
    
 
 0.573
Ttc29
Tetratricopeptide repeat protein 29.
   
 
 0.554
Cstdc1
Cystatin-14; May play a specialized role in spermatogenesis.
   
  
 0.505
Lyzl1
Lysozyme-like protein 1.
   
  
 0.464
Glipr1l1
GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.
   
  
 0.463
Ccer1
Coiled-coil domain-containing glutamate-rich protein 1.
   
 
 0.459
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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