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Mccc1 protein (mouse) - STRING interaction network
"Mccc1" - Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial in Mus musculus
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Mccc1Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (717 aa)    
Predicted Functional Partners:
Mccc2
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (563 aa)
 
  0.997
Pccb
Propionyl-CoA carboxylase beta chain, mitochondrial; Propionyl Coenzyme A carboxylase, beta polypeptide (541 aa)
 
  0.987
Hlcs
Biotin--protein ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (By similarity) (722 aa)
       
  0.968
Ivd
Isovaleryl-CoA dehydrogenase, mitochondrial; Isovaleryl coenzyme A dehydrogenase; Belongs to the acyl-CoA dehydrogenase family (424 aa)
   
 
  0.961
Echs1
Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family (290 aa)
   
  0.951
Auh
Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA (By similarity). Also has itaconyl- CoA hydratase activity by converting itaconyl-CoA into citramalyl- CoA in the C5-dicarboxylate catabolism pathway (By similarity). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (By similarity). Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs (314 aa)
   
  0.937
Hadha
Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family (763 aa)
   
  0.937
Acadm
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (421 aa)
   
 
  0.931
Ehhadh
Peroxisomal bifunctional enzyme; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family (718 aa)
   
  0.924
Pcca
Propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-Coenzyme A carboxylase, alpha polypeptide (724 aa)
   
 
0.923
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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