STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tchhl1Trichohyalin-like protein 1; Belongs to the S-100 family. (638 aa)    
Predicted Functional Partners:
Lelp1
Late cornified envelope-like proline-rich protein 1; Belongs to the cornifin (SPRR) family.
   
 
 0.712
Crnn
Cornulin.
  
 
0.706
Sprr4
Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity).
   
  
 0.672
Kprp
Keratinocyte proline-rich protein.
   
 
 0.652
Vsig10l
V-set and immunoglobulin domain-containing protein 10-like.
      
 0.647
Rpf2
Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family.
    
 
 0.610
S100a2
S100 calcium-binding protein A2.
      
 0.609
S100a3
Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity).
   
 
 0.601
Dlec1
Deleted in lung and esophageal cancer protein 1 homolog; May act as a tumor suppressor by inhibiting cell proliferation.
   
 
 0.595
Hrnr
Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family.
   
  
 0.566
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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