| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| 1700029F12Rik | Atp8b3 | ENSMUSP00000088938 | ENSMUSP00000020383 | RIKEN cDNA 1700029F12 gene. | Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida; Belon [...] | 0.999 |
| 1700029F12Rik | Bspry | ENSMUSP00000088938 | ENSMUSP00000030088 | RIKEN cDNA 1700029F12 gene. | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.999 |
| Atp8b3 | 1700029F12Rik | ENSMUSP00000020383 | ENSMUSP00000088938 | Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida; Belon [...] | RIKEN cDNA 1700029F12 gene. | 0.999 |
| Atp8b3 | Bspry | ENSMUSP00000020383 | ENSMUSP00000030088 | Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida; Belon [...] | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.999 |
| Bspry | 1700029F12Rik | ENSMUSP00000030088 | ENSMUSP00000088938 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | RIKEN cDNA 1700029F12 gene. | 0.999 |
| Bspry | Atp8b3 | ENSMUSP00000030088 | ENSMUSP00000020383 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida; Belon [...] | 0.999 |
| Bspry | Fsd1 | ENSMUSP00000030088 | ENSMUSP00000011733 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | 0.565 |
| Bspry | Fsd1l | ENSMUSP00000030088 | ENSMUSP00000114931 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | FSD1-like protein. | 0.445 |
| Bspry | Nhlrc1 | ENSMUSP00000030088 | ENSMUSP00000054990 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] | 0.543 |
| Bspry | Rnf207 | ENSMUSP00000030088 | ENSMUSP00000075540 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | 0.641 |
| Bspry | S100g | ENSMUSP00000030088 | ENSMUSP00000045120 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Protein S100-G; Belongs to the S-100 family. | 0.529 |
| Bspry | Slc31a2 | ENSMUSP00000030088 | ENSMUSP00000081578 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | 0.459 |
| Bspry | Snrpa1 | ENSMUSP00000030088 | ENSMUSP00000117947 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.446 |
| Bspry | Wnk3 | ENSMUSP00000030088 | ENSMUSP00000139037 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A1, SLC12A2, SLC12A3, SCNN1A, SCNN1B, SCNN1D and SGK1. Inhibits SLC12A4, SLC12A5, SLC12A6 and SLC12A7. Phosphorylates WNK4. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase- dependent pathway. Inhi [...] | 0.539 |
| Fsd1 | Bspry | ENSMUSP00000011733 | ENSMUSP00000030088 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.565 |
| Fsd1 | Rnf207 | ENSMUSP00000011733 | ENSMUSP00000075540 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | 0.520 |
| Fsd1l | Bspry | ENSMUSP00000114931 | ENSMUSP00000030088 | FSD1-like protein. | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.445 |
| Fsd1l | Nhlrc1 | ENSMUSP00000114931 | ENSMUSP00000054990 | FSD1-like protein. | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] | 0.411 |
| Fsd1l | Rnf207 | ENSMUSP00000114931 | ENSMUSP00000075540 | FSD1-like protein. | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | 0.497 |
| Nhlrc1 | Bspry | ENSMUSP00000054990 | ENSMUSP00000030088 | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.543 |
