Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bspry | Cdc26 | ENSMUSP00000030088 | ENSMUSP00000081573 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | 0.481 |
| Bspry | Cspp1 | ENSMUSP00000030088 | ENSMUSP00000068804 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | 0.520 |
| Bspry | Emc8 | ENSMUSP00000030088 | ENSMUSP00000034277 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | ER membrane protein complex subunit 8; Belongs to the EMC8/EMC9 family. | 0.474 |
| Bspry | Hdhd3 | ENSMUSP00000030088 | ENSMUSP00000036337 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Haloacid dehalogenase-like hydrolase domain-containing protein 3; Belongs to the HAD-like hydrolase superfamily. | 0.474 |
| Bspry | Nif3l1 | ENSMUSP00000030088 | ENSMUSP00000084799 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. | 0.522 |
| Bspry | Prpf4 | ENSMUSP00000030088 | ENSMUSP00000081572 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | U4/U6 small nuclear ribonucleoprotein Prp4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). | 0.448 |
| Bspry | Rnf183 | ENSMUSP00000030088 | ENSMUSP00000103079 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity). | 0.452 |
| Bspry | Trpv5 | ENSMUSP00000030088 | ENSMUSP00000031901 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit [...] | 0.511 |
| Bspry | Tspan1 | ENSMUSP00000030088 | ENSMUSP00000030465 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Tetraspanin-1. | 0.461 |
| Bspry | Wnk3 | ENSMUSP00000030088 | ENSMUSP00000139037 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A1, SLC12A2, SLC12A3, SCNN1A, SCNN1B, SCNN1D and SGK1. Inhibits SLC12A4, SLC12A5, SLC12A6 and SLC12A7. Phosphorylates WNK4. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase- dependent pathway. Inhi [...] | 0.542 |
| Cdc26 | Bspry | ENSMUSP00000081573 | ENSMUSP00000030088 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.481 |
| Cdc26 | Cspp1 | ENSMUSP00000081573 | ENSMUSP00000068804 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | 0.473 |
| Cdc26 | Emc8 | ENSMUSP00000081573 | ENSMUSP00000034277 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | ER membrane protein complex subunit 8; Belongs to the EMC8/EMC9 family. | 0.506 |
| Cdc26 | Hdhd3 | ENSMUSP00000081573 | ENSMUSP00000036337 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | Haloacid dehalogenase-like hydrolase domain-containing protein 3; Belongs to the HAD-like hydrolase superfamily. | 0.447 |
| Cdc26 | Nif3l1 | ENSMUSP00000081573 | ENSMUSP00000084799 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. | 0.510 |
| Cdc26 | Prpf4 | ENSMUSP00000081573 | ENSMUSP00000081572 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | U4/U6 small nuclear ribonucleoprotein Prp4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). | 0.413 |
| Cspp1 | Bspry | ENSMUSP00000068804 | ENSMUSP00000030088 | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity. | 0.520 |
| Cspp1 | Cdc26 | ENSMUSP00000068804 | ENSMUSP00000081573 | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] | 0.473 |
| Cspp1 | Emc8 | ENSMUSP00000068804 | ENSMUSP00000034277 | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | ER membrane protein complex subunit 8; Belongs to the EMC8/EMC9 family. | 0.451 |
| Cspp1 | Hdhd3 | ENSMUSP00000068804 | ENSMUSP00000036337 | Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization. | Haloacid dehalogenase-like hydrolase domain-containing protein 3; Belongs to the HAD-like hydrolase superfamily. | 0.474 |
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