node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Becn1 | Glipr2 | ENSMUSP00000119369 | ENSMUSP00000030202 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K comp [...] | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.827 |
Becn1 | Rubcn | ENSMUSP00000119369 | ENSMUSP00000087114 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K comp [...] | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity). | 0.998 |
Becn1 | Uvrag | ENSMUSP00000119369 | ENSMUSP00000045297 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K comp [...] | UV radiation resistance-associated protein; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3- phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation [...] | 0.999 |
Cnn2 | Glipr2 | ENSMUSP00000004784 | ENSMUSP00000030202 | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.418 |
Crip2 | Glipr2 | ENSMUSP00000081943 | ENSMUSP00000030202 | Cysteine-rich protein 2. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.508 |
Crispld1 | Glipr2 | ENSMUSP00000092686 | ENSMUSP00000030202 | Cysteine-rich secretory protein LCCL domain-containing 1. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.437 |
Glipr1 | Glipr2 | ENSMUSP00000123990 | ENSMUSP00000030202 | Glioma pathogenesis-related protein 1. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.413 |
Glipr2 | Becn1 | ENSMUSP00000030202 | ENSMUSP00000119369 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K comp [...] | 0.827 |
Glipr2 | Cnn2 | ENSMUSP00000030202 | ENSMUSP00000004784 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | 0.418 |
Glipr2 | Crip2 | ENSMUSP00000030202 | ENSMUSP00000081943 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Cysteine-rich protein 2. | 0.508 |
Glipr2 | Crispld1 | ENSMUSP00000030202 | ENSMUSP00000092686 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Cysteine-rich secretory protein LCCL domain-containing 1. | 0.437 |
Glipr2 | Glipr1 | ENSMUSP00000030202 | ENSMUSP00000123990 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Glioma pathogenesis-related protein 1. | 0.413 |
Glipr2 | Pi15 | ENSMUSP00000030202 | ENSMUSP00000085826 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.530 |
Glipr2 | Plac8l1 | ENSMUSP00000030202 | ENSMUSP00000080111 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | PLAC8-like protein 1; Belongs to the cornifelin family. | 0.429 |
Glipr2 | R3hdml | ENSMUSP00000030202 | ENSMUSP00000105043 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Peptidase inhibitor R3HDML; Putative serine protease inhibitor; Belongs to the CRISP family. | 0.560 |
Glipr2 | Rubcn | ENSMUSP00000030202 | ENSMUSP00000087114 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity). | 0.539 |
Glipr2 | Uvrag | ENSMUSP00000030202 | ENSMUSP00000045297 | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | UV radiation resistance-associated protein; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3- phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation [...] | 0.408 |
Pi15 | Glipr2 | ENSMUSP00000085826 | ENSMUSP00000030202 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.530 |
Plac8l1 | Glipr2 | ENSMUSP00000080111 | ENSMUSP00000030202 | PLAC8-like protein 1; Belongs to the cornifelin family. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.429 |
R3hdml | Glipr2 | ENSMUSP00000105043 | ENSMUSP00000030202 | Peptidase inhibitor R3HDML; Putative serine protease inhibitor; Belongs to the CRISP family. | Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. | 0.560 |