node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acaa1a | Acaa1b | ENSMUSP00000042351 | ENSMUSP00000010795 | 3-ketoacyl-CoA thiolase A, peroxisomal. | 3-ketoacyl-CoA thiolase B, peroxisomal. | 0.919 |
Acaa1a | Acot8 | ENSMUSP00000042351 | ENSMUSP00000099383 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.708 |
Acaa1a | Acox1 | ENSMUSP00000042351 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.991 |
Acaa1a | Acox3 | ENSMUSP00000042351 | ENSMUSP00000063412 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. | 0.973 |
Acaa1a | Hsd17b4 | ENSMUSP00000042351 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.980 |
Acaa1a | Pex5 | ENSMUSP00000042351 | ENSMUSP00000108151 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.670 |
Acaa1a | Pex5l | ENSMUSP00000042351 | ENSMUSP00000142196 | 3-ketoacyl-CoA thiolase A, peroxisomal. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Belongs to the peroxisomal targeting signal receptor family. | 0.480 |
Acaa1a | Scp2 | ENSMUSP00000042351 | ENSMUSP00000030340 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. | 0.970 |
Acaa1b | Acaa1a | ENSMUSP00000010795 | ENSMUSP00000042351 | 3-ketoacyl-CoA thiolase B, peroxisomal. | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.919 |
Acaa1b | Acot8 | ENSMUSP00000010795 | ENSMUSP00000099383 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 0.597 |
Acaa1b | Acox1 | ENSMUSP00000010795 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.987 |
Acaa1b | Acox3 | ENSMUSP00000010795 | ENSMUSP00000063412 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. | 0.972 |
Acaa1b | Hsd17b4 | ENSMUSP00000010795 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.971 |
Acaa1b | Pex5 | ENSMUSP00000010795 | ENSMUSP00000108151 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.792 |
Acaa1b | Pex5l | ENSMUSP00000010795 | ENSMUSP00000142196 | 3-ketoacyl-CoA thiolase B, peroxisomal. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Belongs to the peroxisomal targeting signal receptor family. | 0.456 |
Acaa1b | Scp2 | ENSMUSP00000010795 | ENSMUSP00000030340 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. | 0.966 |
Acaa1b | Slc27a5 | ENSMUSP00000010795 | ENSMUSP00000032539 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Catalyzes the activation of the primary bile acid, cholic acid. Both primary bile acid (chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (By similarity). In [...] | 0.424 |
Acot8 | Acaa1a | ENSMUSP00000099383 | ENSMUSP00000042351 | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.708 |
Acot8 | Acaa1b | ENSMUSP00000099383 | ENSMUSP00000010795 | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | 3-ketoacyl-CoA thiolase B, peroxisomal. | 0.597 |
Acot8 | Acox1 | ENSMUSP00000099383 | ENSMUSP00000063325 | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.580 |