| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Atp7b | Lipt1 | ENSMUSP00000006742 | ENSMUSP00000038739 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.708 |
| Atp7b | Mt1 | ENSMUSP00000006742 | ENSMUSP00000034215 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | 0.429 |
| Atp7b | Mtf1 | ENSMUSP00000006742 | ENSMUSP00000030723 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | 0.648 |
| Atp7b | Slc30a1 | ENSMUSP00000006742 | ENSMUSP00000042410 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.570 |
| Atp7b | Slc30a5 | ENSMUSP00000006742 | ENSMUSP00000065764 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Zinc transporter 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.462 |
| Atp7b | Slc31a1 | ENSMUSP00000006742 | ENSMUSP00000081574 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | 0.935 |
| Atp7b | Slc39a8 | ENSMUSP00000006742 | ENSMUSP00000128245 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain. | 0.429 |
| Csrp1 | Mtf1 | ENSMUSP00000095169 | ENSMUSP00000030723 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | 0.764 |
| Lipt1 | Atp7b | ENSMUSP00000038739 | ENSMUSP00000006742 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | 0.708 |
| Lipt1 | Mtf1 | ENSMUSP00000038739 | ENSMUSP00000030723 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | 0.634 |
| Lipt1 | Slc31a1 | ENSMUSP00000038739 | ENSMUSP00000081574 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | 0.764 |
| Mt1 | Atp7b | ENSMUSP00000034215 | ENSMUSP00000006742 | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | 0.429 |
| Mt1 | Mtf1 | ENSMUSP00000034215 | ENSMUSP00000030723 | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | 0.898 |
| Mt1 | Slc30a1 | ENSMUSP00000034215 | ENSMUSP00000042410 | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.684 |
| Mt1 | Slc30a5 | ENSMUSP00000034215 | ENSMUSP00000065764 | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | Zinc transporter 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.404 |
| Mt1 | Slc31a1 | ENSMUSP00000034215 | ENSMUSP00000081574 | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | 0.406 |
| Mtf1 | Atp7b | ENSMUSP00000030723 | ENSMUSP00000006742 | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. | 0.648 |
| Mtf1 | Csrp1 | ENSMUSP00000030723 | ENSMUSP00000095169 | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | Cysteine and glycine-rich protein 1; Could play a role in neuronal development. | 0.764 |
| Mtf1 | Lipt1 | ENSMUSP00000030723 | ENSMUSP00000038739 | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.634 |
| Mtf1 | Mt1 | ENSMUSP00000030723 | ENSMUSP00000034215 | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). | Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. | 0.898 |
