Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Cgref1Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines (By similarity). (325 aa)    
Predicted Functional Partners:
Cgrrf1
Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines.
      
 0.577
Tmem130
Transmembrane protein 130.
   
  
 0.487
Slc13a5
Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
   
  
 0.455
Efcc1
EF-hand and coiled-coil domain-containing protein 1.
   
  
 0.439
Ckap2
Cytoskeleton-associated protein 2; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner; Belongs to the CKAP2 family.
  
  
 0.431
Preb
Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
 
 
  
 0.425
Efhc2
EF-hand domain-containing family member C2.
   
  
 0.420
Pcnp
PEST proteolytic signal-containing nuclear protein; May be involved in cell cycle regulation.
   
  
 0.415
Arl16
ADP-ribosylation factor-like 16.
   
  
 0.404
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.