node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ambn | Amelx | ENSMUSP00000142944 | ENSMUSP00000065966 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.992 |
Ambn | Amtn | ENSMUSP00000142944 | ENSMUSP00000073081 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.961 |
Ambn | Enam | ENSMUSP00000142944 | ENSMUSP00000031222 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.991 |
Ambn | Fam20a | ENSMUSP00000142944 | ENSMUSP00000020938 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.794 |
Ambn | Fam83h | ENSMUSP00000142944 | ENSMUSP00000126453 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.703 |
Ambn | Klk1b4 | ENSMUSP00000142944 | ENSMUSP00000076576 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein 1-related peptidase-like b4. | 0.792 |
Ambn | Klk4 | ENSMUSP00000142944 | ENSMUSP00000007161 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.874 |
Ambn | Mmp20 | ENSMUSP00000142944 | ENSMUSP00000034487 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.872 |
Ambn | Odam | ENSMUSP00000142944 | ENSMUSP00000117898 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.752 |
Ambn | Tuft1 | ENSMUSP00000142944 | ENSMUSP00000006123 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family. | 0.944 |
Amelx | Ambn | ENSMUSP00000065966 | ENSMUSP00000142944 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Ameloblastin; Involved in the mineralization and structural organization of enamel. | 0.992 |
Amelx | Amtn | ENSMUSP00000065966 | ENSMUSP00000073081 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.911 |
Amelx | Enam | ENSMUSP00000065966 | ENSMUSP00000031222 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.990 |
Amelx | Fam20a | ENSMUSP00000065966 | ENSMUSP00000020938 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.782 |
Amelx | Fam83h | ENSMUSP00000065966 | ENSMUSP00000126453 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.810 |
Amelx | Klk1b4 | ENSMUSP00000065966 | ENSMUSP00000076576 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein 1-related peptidase-like b4. | 0.802 |
Amelx | Klk4 | ENSMUSP00000065966 | ENSMUSP00000007161 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.917 |
Amelx | Mmp20 | ENSMUSP00000065966 | ENSMUSP00000034487 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.923 |
Amelx | Odam | ENSMUSP00000065966 | ENSMUSP00000117898 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.732 |
Amelx | Tuft1 | ENSMUSP00000065966 | ENSMUSP00000006123 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family. | 0.939 |