node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Evx1 | Fgf8 | ENSMUSP00000031787 | ENSMUSP00000026241 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | 0.463 |
Evx1 | Foxa2 | ENSMUSP00000031787 | ENSMUSP00000105590 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | 0.525 |
Evx1 | Grrp1 | ENSMUSP00000031787 | ENSMUSP00000060143 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Protein FAM110D; Belongs to the FAM110 family. | 0.494 |
Evx1 | Isl1 | ENSMUSP00000031787 | ENSMUSP00000044879 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences (By similarity [...] | 0.599 |
Evx1 | Isl2 | ENSMUSP00000031787 | ENSMUSP00000034869 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | 0.538 |
Evx1 | Lhx1 | ENSMUSP00000031787 | ENSMUSP00000018842 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.600 |
Evx1 | Lhx3 | ENSMUSP00000031787 | ENSMUSP00000028302 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pou1f1/Pit-1. | 0.549 |
Evx1 | Pax2 | ENSMUSP00000031787 | ENSMUSP00000134661 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. | 0.551 |
Evx1 | Spata31d1b | ENSMUSP00000031787 | ENSMUSP00000130813 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | Spermatogenesis-associated 31 subfamily D, member 1B. | 0.515 |
Evx1 | T | ENSMUSP00000031787 | ENSMUSP00000074236 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. | 0.536 |
Fgf8 | Evx1 | ENSMUSP00000026241 | ENSMUSP00000031787 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | 0.463 |
Fgf8 | Foxa2 | ENSMUSP00000026241 | ENSMUSP00000105590 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | 0.736 |
Fgf8 | Isl1 | ENSMUSP00000026241 | ENSMUSP00000044879 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences (By similarity [...] | 0.643 |
Fgf8 | Lhx1 | ENSMUSP00000026241 | ENSMUSP00000018842 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.530 |
Fgf8 | Pax2 | ENSMUSP00000026241 | ENSMUSP00000134661 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. | 0.644 |
Fgf8 | T | ENSMUSP00000026241 | ENSMUSP00000074236 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. | 0.698 |
Foxa2 | Evx1 | ENSMUSP00000105590 | ENSMUSP00000031787 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate. | 0.525 |
Foxa2 | Fgf8 | ENSMUSP00000105590 | ENSMUSP00000026241 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. | 0.736 |
Foxa2 | Isl1 | ENSMUSP00000105590 | ENSMUSP00000044879 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences (By similarity [...] | 0.683 |
Foxa2 | Lhx1 | ENSMUSP00000105590 | ENSMUSP00000018842 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.572 |