STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prss37Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). (237 aa)    
Predicted Functional Partners:
Prss54
Inactive serine protease 54.
   
  
 0.742
Adam3
A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct.
   
  
 0.730
Prss44
Serine protease 44; Belongs to the peptidase S1 family.
   
  
 0.700
Pdilt
Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.
   
  
 0.692
Prss55
Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family.
   
  
 0.683
Prss46
Serine protease 46; Belongs to the peptidase S1 family.
   
  
 0.649
Adam2
Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity).
   
  
 0.639
Calr3
Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility.
   
 
 0.635
Pradc1
Protease-associated domain-containing protein 1.
      
 0.629
Rnase10
Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity.
   
  
 0.624
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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