node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gm49711 | Mrpl21 | ENSMUSP00000156255 | ENSMUSP00000025745 | Predicted gene, 49711. | 39S ribosomal protein L21, mitochondrial. | 0.978 |
Gm49711 | Mrps6 | ENSMUSP00000156255 | ENSMUSP00000037631 | Predicted gene, 49711. | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 0.554 |
Gm49711 | Rps20 | ENSMUSP00000156255 | ENSMUSP00000120528 | Predicted gene, 49711. | 40S ribosomal protein S20. | 0.920 |
Gm49711 | Ssbp1 | ENSMUSP00000156255 | ENSMUSP00000031971 | Predicted gene, 49711. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.889 |
Mrpl21 | Gm49711 | ENSMUSP00000025745 | ENSMUSP00000156255 | 39S ribosomal protein L21, mitochondrial. | Predicted gene, 49711. | 0.978 |
Mrpl21 | Mrps6 | ENSMUSP00000025745 | ENSMUSP00000037631 | 39S ribosomal protein L21, mitochondrial. | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 0.979 |
Mrpl21 | Rps20 | ENSMUSP00000025745 | ENSMUSP00000120528 | 39S ribosomal protein L21, mitochondrial. | 40S ribosomal protein S20. | 0.982 |
Mrpl21 | Ssbp1 | ENSMUSP00000025745 | ENSMUSP00000031971 | 39S ribosomal protein L21, mitochondrial. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.903 |
Mrps6 | Gm49711 | ENSMUSP00000037631 | ENSMUSP00000156255 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | Predicted gene, 49711. | 0.554 |
Mrps6 | Mrpl21 | ENSMUSP00000037631 | ENSMUSP00000025745 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 39S ribosomal protein L21, mitochondrial. | 0.979 |
Mrps6 | Rps20 | ENSMUSP00000037631 | ENSMUSP00000120528 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 40S ribosomal protein S20. | 0.920 |
Mrps6 | Ssbp1 | ENSMUSP00000037631 | ENSMUSP00000031971 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.889 |
Polg | Polrmt | ENSMUSP00000073551 | ENSMUSP00000020580 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | 0.927 |
Polg | Rnaseh1 | ENSMUSP00000073551 | ENSMUSP00000020959 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.859 |
Polg | Ssbp1 | ENSMUSP00000073551 | ENSMUSP00000031971 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.996 |
Polg | Tfam | ENSMUSP00000073551 | ENSMUSP00000090086 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymeras [...] | 0.964 |
Polg | Twnk | ENSMUSP00000073551 | ENSMUSP00000026227 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function infered to be critical for lifetime maintenance of mtDNA integrity. May be a key regulator of mtDNA copy number in mammals. | 0.997 |
Polrmt | Polg | ENSMUSP00000020580 | ENSMUSP00000073551 | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family. | 0.927 |
Polrmt | Rnaseh1 | ENSMUSP00000020580 | ENSMUSP00000020959 | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family. | 0.708 |
Polrmt | Ssbp1 | ENSMUSP00000020580 | ENSMUSP00000031971 | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.898 |