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Reg3g protein (mouse) - STRING interaction network
"Reg3g" - Regenerating islet-derived protein 3-gamma in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Reg3gRegenerating islet-derived protein 3-gamma; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiati [...] (174 aa)    
Predicted Functional Partners:
Reg3b
Regenerating islet-derived protein 3-beta; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues (175 aa)
     
 
0.939
Reg3a
Regenerating islet-derived protein 3-alpha; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (175 aa)
     
 
0.914
Try4
Trypsin 4; Belongs to the peptidase S1 family (246 aa)
     
  0.912
Prss1
Protease, serine 1 (trypsin 1); Belongs to the peptidase S1 family (246 aa)
     
  0.912
Try10
Trypsin 10; Belongs to the peptidase S1 family (246 aa)
     
  0.912
Prss2
Anionic trypsin-2; Protease, serine 2 (246 aa)
     
  0.911
Prss3
Protease, serine 3; Belongs to the peptidase S1 family (246 aa)
     
  0.910
Gm5771
Predicted gene, EG436523; Predicted gene 5771; Belongs to the peptidase S1 family (245 aa)
     
  0.906
Gm10334
Predicted gene 10334; Belongs to the peptidase S1 family (246 aa)
     
  0.906
Reg3d
Regenerating islet-derived 3 delta (175 aa)
     
 
0.905
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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