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Lag3 protein (mouse) - STRING interaction network
"Lag3" - Lymphocyte activation gene 3 protein in Mus musculus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Lag3Lymphocyte activation gene 3 protein; Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity) (521 aa)    
Predicted Functional Partners:
H2-Ab1
Histocompatibility 2, class II antigen A, beta 1; Belongs to the MHC class II family (265 aa)
     
 
  0.929
Havcr2
Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in [...] (281 aa)
           
  0.910
H2-Aa
Histocompatibility 2, class II antigen A, alpha (256 aa)
     
 
  0.903
H2-Eb1
Histocompatibility 2, class II antigen E beta; Belongs to the MHC class II family (264 aa)
     
 
  0.902
H2-Eb2
Histocompatibility 2, class II antigen E beta2; Belongs to the MHC class II family (287 aa)
     
 
  0.902
Ctla4
Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (223 aa)
     
   
  0.852
Cd274
Programmed cell death 1 ligand 1; Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family (290 aa)
     
   
  0.841
Pdcd1
Programmed cell death protein 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors (By similarity) (288 aa)
     
   
  0.836
Cd160
CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules (185 aa)
           
  0.833
Tbx21
T-box transcription factor TBX21; Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and a [...] (530 aa)
     
   
  0.782
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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