Gp2 protein (mouse) - STRING interaction network

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Score

Gp2

Pancreatic secretory granule membrane major glycoprotein GP2. (534 aa)

Predicted Functional Partners:

Gtpbp1

0.933

Cuzd1

0.851

Pla2g1b

0.844

Cela3b

0.800

Gp5

0.761

Npc1

0.736

Ppy

0.733

Gp9

0.704

Furin

0.703

Tff2

0.686

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cela3b	Cuzd1	ENSMUSP00000099581	ENSMUSP00000037168	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	0.567
Cela3b	Gp2	ENSMUSP00000099581	ENSMUSP00000033255	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic secretory granule membrane major glycoprotein GP2.	0.800
Cela3b	Pla2g1b	ENSMUSP00000099581	ENSMUSP00000031495	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family.	0.801
Cela3b	Ppy	ENSMUSP00000099581	ENSMUSP00000017460	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.	0.765
Cela3b	Tff2	ENSMUSP00000099581	ENSMUSP00000024826	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).	0.519
Cuzd1	Cela3b	ENSMUSP00000037168	ENSMUSP00000099581	CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	0.567
Cuzd1	Gp2	ENSMUSP00000037168	ENSMUSP00000033255	CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	Pancreatic secretory granule membrane major glycoprotein GP2.	0.851
Cuzd1	Pla2g1b	ENSMUSP00000037168	ENSMUSP00000031495	CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family.	0.935
Furin	Gp2	ENSMUSP00000113793	ENSMUSP00000033255	Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Belongs to the peptidase S8 family. Furin subfamily.	Pancreatic secretory granule membrane major glycoprotein GP2.	0.703
Furin	Gtpbp1	ENSMUSP00000113793	ENSMUSP00000043575	Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Belongs to the peptidase S8 family. Furin subfamily.	GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).	0.679
Furin	Npc1	ENSMUSP00000113793	ENSMUSP00000025279	Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Belongs to the peptidase S8 family. Furin subfamily.	NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for main [...]	0.446
Gp2	Cela3b	ENSMUSP00000033255	ENSMUSP00000099581	Pancreatic secretory granule membrane major glycoprotein GP2.	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.	0.800
Gp2	Cuzd1	ENSMUSP00000033255	ENSMUSP00000037168	Pancreatic secretory granule membrane major glycoprotein GP2.	CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	0.851
Gp2	Furin	ENSMUSP00000033255	ENSMUSP00000113793	Pancreatic secretory granule membrane major glycoprotein GP2.	Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Belongs to the peptidase S8 family. Furin subfamily.	0.703
Gp2	Gp5	ENSMUSP00000033255	ENSMUSP00000051895	Pancreatic secretory granule membrane major glycoprotein GP2.	Platelet glycoprotein V; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity).	0.761
Gp2	Gp9	ENSMUSP00000033255	ENSMUSP00000032133	Pancreatic secretory granule membrane major glycoprotein GP2.	Platelet glycoprotein IX; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity).	0.704
Gp2	Gtpbp1	ENSMUSP00000033255	ENSMUSP00000043575	Pancreatic secretory granule membrane major glycoprotein GP2.	GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).	0.933
Gp2	Npc1	ENSMUSP00000033255	ENSMUSP00000025279	Pancreatic secretory granule membrane major glycoprotein GP2.	NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for main [...]	0.736
Gp2	Pla2g1b	ENSMUSP00000033255	ENSMUSP00000031495	Pancreatic secretory granule membrane major glycoprotein GP2.	Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family.	0.844
Gp2	Ppy	ENSMUSP00000033255	ENSMUSP00000017460	Pancreatic secretory granule membrane major glycoprotein GP2.	Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.	0.733