node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acan | Bgn | ENSMUSP00000032835 | ENSMUSP00000033741 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.884 |
Acan | Col1a1 | ENSMUSP00000032835 | ENSMUSP00000001547 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.819 |
Acan | Dcn | ENSMUSP00000032835 | ENSMUSP00000100924 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.940 |
Acan | Fmod | ENSMUSP00000032835 | ENSMUSP00000035489 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. | 0.929 |
Acan | Mkx | ENSMUSP00000032835 | ENSMUSP00000078718 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation. | 0.487 |
Acan | Mmp13 | ENSMUSP00000032835 | ENSMUSP00000015394 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.910 |
Acan | Scx | ENSMUSP00000032835 | ENSMUSP00000043668 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. | 0.666 |
Acan | Thbs4 | ENSMUSP00000032835 | ENSMUSP00000022213 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] | 0.474 |
Acan | Tnmd | ENSMUSP00000032835 | ENSMUSP00000033602 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenomodulin; May be an angiogenesis inhibitor; Belongs to the chondromodulin-1 family. | 0.673 |
Bgn | Acan | ENSMUSP00000033741 | ENSMUSP00000032835 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.884 |
Bgn | Col1a1 | ENSMUSP00000033741 | ENSMUSP00000001547 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.935 |
Bgn | Dcn | ENSMUSP00000033741 | ENSMUSP00000100924 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.987 |
Bgn | Fmod | ENSMUSP00000033741 | ENSMUSP00000035489 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis. | 0.933 |
Bgn | Mkx | ENSMUSP00000033741 | ENSMUSP00000078718 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation. | 0.564 |
Bgn | Mmp13 | ENSMUSP00000033741 | ENSMUSP00000015394 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.568 |
Bgn | Scx | ENSMUSP00000033741 | ENSMUSP00000043668 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. | 0.652 |
Bgn | Thbs4 | ENSMUSP00000033741 | ENSMUSP00000022213 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] | 0.552 |
Bgn | Tnmd | ENSMUSP00000033741 | ENSMUSP00000033602 | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Tenomodulin; May be an angiogenesis inhibitor; Belongs to the chondromodulin-1 family. | 0.690 |
Col1a1 | Acan | ENSMUSP00000001547 | ENSMUSP00000032835 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.819 |
Col1a1 | Bgn | ENSMUSP00000001547 | ENSMUSP00000033741 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.935 |