| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Alb | Serpina7 | ENSMUSP00000031314 | ENSMUSP00000033626 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | 0.687 |
| Alb | Serpinc1 | ENSMUSP00000031314 | ENSMUSP00000068971 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.823 |
| Alb | Serpinf2 | ENSMUSP00000031314 | ENSMUSP00000048704 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin (By similarity). | 0.591 |
| Alb | Slc16a10 | ENSMUSP00000031314 | ENSMUSP00000090227 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Monocarboxylate transporter 10; Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells. | 0.412 |
| Alb | Slc16a2 | ENSMUSP00000031314 | ENSMUSP00000037629 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.483 |
| Alb | Tg | ENSMUSP00000031314 | ENSMUSP00000070239 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). | 0.656 |
| Alb | Ttr | ENSMUSP00000031314 | ENSMUSP00000074783 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. | 0.931 |
| Serpina12 | Serpina3c | ENSMUSP00000045572 | ENSMUSP00000082125 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | Serine protease inhibitor A3C. | 0.593 |
| Serpina12 | Serpina7 | ENSMUSP00000045572 | ENSMUSP00000033626 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | 0.647 |
| Serpina12 | Serpinc1 | ENSMUSP00000045572 | ENSMUSP00000068971 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.460 |
| Serpina12 | Serpini2 | ENSMUSP00000045572 | ENSMUSP00000046943 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | Serpin I2; Belongs to the serpin family. | 0.730 |
| Serpina3c | Serpina12 | ENSMUSP00000082125 | ENSMUSP00000045572 | Serine protease inhibitor A3C. | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | 0.593 |
| Serpina3c | Serpina7 | ENSMUSP00000082125 | ENSMUSP00000033626 | Serine protease inhibitor A3C. | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | 0.873 |
| Serpina3c | Serpinc1 | ENSMUSP00000082125 | ENSMUSP00000068971 | Serine protease inhibitor A3C. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.656 |
| Serpina3c | Serpinf2 | ENSMUSP00000082125 | ENSMUSP00000048704 | Serine protease inhibitor A3C. | Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin (By similarity). | 0.456 |
| Serpina3c | Serpini2 | ENSMUSP00000082125 | ENSMUSP00000046943 | Serine protease inhibitor A3C. | Serpin I2; Belongs to the serpin family. | 0.679 |
| Serpina7 | Alb | ENSMUSP00000033626 | ENSMUSP00000031314 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.687 |
| Serpina7 | Serpina12 | ENSMUSP00000033626 | ENSMUSP00000045572 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. | 0.647 |
| Serpina7 | Serpina3c | ENSMUSP00000033626 | ENSMUSP00000082125 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | Serine protease inhibitor A3C. | 0.873 |
| Serpina7 | Serpinc1 | ENSMUSP00000033626 | ENSMUSP00000068971 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.664 |
