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Hccs protein (mouse) - STRING interaction network
"Hccs" - Cytochrome c-type heme lyase in Mus musculus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
HccsCytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c (272 aa)    
Predicted Functional Partners:
Cox10
Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O (443 aa)
     
 
  0.952
Fech
Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX (422 aa)
     
 
  0.916
Hmox2
Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter (315 aa)
     
 
  0.909
Hmox1
Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis (289 aa)
         
  0.901
Cyc1
Cytochrome c1, heme protein, mitochondrial; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain (325 aa)
     
 
  0.761
Gm10273
Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (209 aa)
     
   
  0.656
Timm23
Translocase of inner mitochondrial membrane 23 (209 aa)
     
   
  0.656
Cox15
Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A (413 aa)
 
 
 
  0.650
Moxd1
Monooxygenase, DBH-like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family (613 aa)
           
  0.647
Arhgap6
Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity) (987 aa)
     
   
  0.640
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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