node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brip1 | Defb8 | ENSMUSP00000043108 | ENSMUSP00000033854 | Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity). | Beta-defensin 8; A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration. | 0.478 |
Brip1 | Palb2 | ENSMUSP00000043108 | ENSMUSP00000095675 | Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity). | Partner and localizer of BRCA2; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombinat [...] | 0.992 |
Defa29 | Defb1 | ENSMUSP00000096489 | ENSMUSP00000051754 | Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.494 |
Defa29 | Defb36 | ENSMUSP00000096489 | ENSMUSP00000059665 | Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. | Beta-defensin 36; Has antibacterial activity; Belongs to the beta-defensin family. | 0.400 |
Defa29 | Defb8 | ENSMUSP00000096489 | ENSMUSP00000033854 | Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. | Beta-defensin 8; A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration. | 0.451 |
Defb1 | Defa29 | ENSMUSP00000051754 | ENSMUSP00000096489 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Alpha-defensin-related sequence 1; Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities; Belongs to the alpha-defensin family. | 0.494 |
Defb1 | Defb12 | ENSMUSP00000051754 | ENSMUSP00000060899 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 12; Has antibacterial activity. | 0.599 |
Defb1 | Defb15 | ENSMUSP00000051754 | ENSMUSP00000059763 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 15; Has antibacterial activity. | 0.451 |
Defb1 | Defb2 | ENSMUSP00000051754 | ENSMUSP00000006745 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family. | 0.448 |
Defb1 | Defb35 | ENSMUSP00000051754 | ENSMUSP00000076067 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 35; Has antibacterial activity. | 0.669 |
Defb1 | Defb36 | ENSMUSP00000051754 | ENSMUSP00000059665 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 36; Has antibacterial activity; Belongs to the beta-defensin family. | 0.557 |
Defb1 | Defb8 | ENSMUSP00000051754 | ENSMUSP00000033854 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | Beta-defensin 8; A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration. | 0.438 |
Defb10 | Defb15 | ENSMUSP00000061533 | ENSMUSP00000059763 | Beta-defensin 10; Has antibacterial activity. | Beta-defensin 15; Has antibacterial activity. | 0.704 |
Defb10 | Defb35 | ENSMUSP00000061533 | ENSMUSP00000076067 | Beta-defensin 10; Has antibacterial activity. | Beta-defensin 35; Has antibacterial activity. | 0.802 |
Defb10 | Defb8 | ENSMUSP00000061533 | ENSMUSP00000033854 | Beta-defensin 10; Has antibacterial activity. | Beta-defensin 8; A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration. | 0.477 |
Defb12 | Defb1 | ENSMUSP00000060899 | ENSMUSP00000051754 | Beta-defensin 12; Has antibacterial activity. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.599 |
Defb12 | Defb15 | ENSMUSP00000060899 | ENSMUSP00000059763 | Beta-defensin 12; Has antibacterial activity. | Beta-defensin 15; Has antibacterial activity. | 0.773 |
Defb12 | Defb8 | ENSMUSP00000060899 | ENSMUSP00000033854 | Beta-defensin 12; Has antibacterial activity. | Beta-defensin 8; A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration. | 0.485 |
Defb15 | Defb1 | ENSMUSP00000059763 | ENSMUSP00000051754 | Beta-defensin 15; Has antibacterial activity. | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family. | 0.451 |
Defb15 | Defb10 | ENSMUSP00000059763 | ENSMUSP00000061533 | Beta-defensin 15; Has antibacterial activity. | Beta-defensin 10; Has antibacterial activity. | 0.704 |