node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr10 | Actr1a | ENSMUSP00000021479 | ENSMUSP00000039844 | Actin-related protein 10; Belongs to the actin family. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.998 |
Actr10 | Actr1b | ENSMUSP00000021479 | ENSMUSP00000047326 | Actin-related protein 10; Belongs to the actin family. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity); Belongs to the actin family. ARP1 subfamily. | 0.981 |
Actr10 | Capzb | ENSMUSP00000021479 | ENSMUSP00000030518 | Actin-related protein 10; Belongs to the actin family. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By sim [...] | 0.938 |
Actr10 | Dctn1 | ENSMUSP00000021479 | ENSMUSP00000109552 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
Actr10 | Dctn2 | ENSMUSP00000021479 | ENSMUSP00000026479 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr10 | Dctn3 | ENSMUSP00000021479 | ENSMUSP00000030158 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.994 |
Actr10 | Dctn4 | ENSMUSP00000021479 | ENSMUSP00000025505 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.999 |
Actr10 | Dctn5 | ENSMUSP00000021479 | ENSMUSP00000033156 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.999 |
Actr10 | Dctn6 | ENSMUSP00000021479 | ENSMUSP00000113716 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. | 0.999 |
Actr10 | Dync1li2 | ENSMUSP00000021479 | ENSMUSP00000045480 | Actin-related protein 10; Belongs to the actin family. | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). | 0.803 |
Actr1a | Actr10 | ENSMUSP00000039844 | ENSMUSP00000021479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Actin-related protein 10; Belongs to the actin family. | 0.998 |
Actr1a | Actr1b | ENSMUSP00000039844 | ENSMUSP00000047326 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity); Belongs to the actin family. ARP1 subfamily. | 0.981 |
Actr1a | Capzb | ENSMUSP00000039844 | ENSMUSP00000030518 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By sim [...] | 0.937 |
Actr1a | Dctn1 | ENSMUSP00000039844 | ENSMUSP00000109552 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.995 |
Actr1a | Dctn2 | ENSMUSP00000039844 | ENSMUSP00000026479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr1a | Dctn3 | ENSMUSP00000039844 | ENSMUSP00000030158 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.992 |
Actr1a | Dctn4 | ENSMUSP00000039844 | ENSMUSP00000025505 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.997 |
Actr1a | Dctn5 | ENSMUSP00000039844 | ENSMUSP00000033156 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.995 |
Actr1a | Dctn6 | ENSMUSP00000039844 | ENSMUSP00000113716 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. | 0.996 |
Actr1a | Dync1li2 | ENSMUSP00000039844 | ENSMUSP00000045480 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). | 0.916 |