node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gdnf | Pdgfrl | ENSMUSP00000022744 | ENSMUSP00000034004 | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. | Platelet-derived growth factor receptor-like protein. | 0.424 |
Pdgfc | Pdgfd | ENSMUSP00000029652 | ENSMUSP00000128388 | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes an [...] | 0.972 |
Pdgfc | Pdgfrl | ENSMUSP00000029652 | ENSMUSP00000034004 | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | Platelet-derived growth factor receptor-like protein. | 0.445 |
Pdgfd | Pdgfc | ENSMUSP00000128388 | ENSMUSP00000029652 | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes an [...] | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | 0.972 |
Pdgfd | Pdgfrl | ENSMUSP00000128388 | ENSMUSP00000034004 | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes an [...] | Platelet-derived growth factor receptor-like protein. | 0.419 |
Pdgfrl | Gdnf | ENSMUSP00000034004 | ENSMUSP00000022744 | Platelet-derived growth factor receptor-like protein. | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. | 0.424 |
Pdgfrl | Pdgfc | ENSMUSP00000034004 | ENSMUSP00000029652 | Platelet-derived growth factor receptor-like protein. | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | 0.445 |
Pdgfrl | Pdgfd | ENSMUSP00000034004 | ENSMUSP00000128388 | Platelet-derived growth factor receptor-like protein. | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes an [...] | 0.419 |
Pdgfrl | Phf6 | ENSMUSP00000034004 | ENSMUSP00000077971 | Platelet-derived growth factor receptor-like protein. | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. | 0.416 |
Pdgfrl | Scoc | ENSMUSP00000034004 | ENSMUSP00000080221 | Platelet-derived growth factor receptor-like protein. | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | 0.470 |
Pdgfrl | Tusc3 | ENSMUSP00000034004 | ENSMUSP00000126080 | Platelet-derived growth factor receptor-like protein. | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] | 0.565 |
Phf6 | Pdgfrl | ENSMUSP00000077971 | ENSMUSP00000034004 | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. | Platelet-derived growth factor receptor-like protein. | 0.416 |
Scoc | Pdgfrl | ENSMUSP00000080221 | ENSMUSP00000034004 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | Platelet-derived growth factor receptor-like protein. | 0.470 |
Tusc3 | Pdgfrl | ENSMUSP00000126080 | ENSMUSP00000034004 | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] | Platelet-derived growth factor receptor-like protein. | 0.565 |