| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Brdt | Pmfbp1 | ENSMUSP00000031215 | ENSMUSP00000034162 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.550 |
| Brdt | Sun5 | ENSMUSP00000031215 | ENSMUSP00000028982 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.480 |
| Brdt | Tsga10 | ENSMUSP00000031215 | ENSMUSP00000048859 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A ; Belongs to the CEP135/TSGA10 family. | 0.540 |
| Cep112 | Hook1 | ENSMUSP00000050597 | ENSMUSP00000030306 | Centrosomal protein of 112 kDa. | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | 0.406 |
| Cep112 | Pmfbp1 | ENSMUSP00000050597 | ENSMUSP00000034162 | Centrosomal protein of 112 kDa. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.662 |
| Cep112 | Spatc1l | ENSMUSP00000050597 | ENSMUSP00000009259 | Centrosomal protein of 112 kDa. | Speriolin-like protein; Belongs to the speriolin family. | 0.545 |
| Cep112 | Sun5 | ENSMUSP00000050597 | ENSMUSP00000028982 | Centrosomal protein of 112 kDa. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.617 |
| Cep112 | Tsga10 | ENSMUSP00000050597 | ENSMUSP00000048859 | Centrosomal protein of 112 kDa. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A ; Belongs to the CEP135/TSGA10 family. | 0.658 |
| Cetn1 | Pmfbp1 | ENSMUSP00000057392 | ENSMUSP00000034162 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.575 |
| Cetn1 | Spatc1l | ENSMUSP00000057392 | ENSMUSP00000009259 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Speriolin-like protein; Belongs to the speriolin family. | 0.425 |
| Cetn1 | Sun5 | ENSMUSP00000057392 | ENSMUSP00000028982 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.636 |
| Cetn1 | Tsga10 | ENSMUSP00000057392 | ENSMUSP00000048859 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A ; Belongs to the CEP135/TSGA10 family. | 0.448 |
| Draxin | Pmfbp1 | ENSMUSP00000030862 | ENSMUSP00000034162 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.540 |
| Hook1 | Cep112 | ENSMUSP00000030306 | ENSMUSP00000050597 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Centrosomal protein of 112 kDa. | 0.406 |
| Hook1 | Pmfbp1 | ENSMUSP00000030306 | ENSMUSP00000034162 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.519 |
| Hook1 | Spata6 | ENSMUSP00000030306 | ENSMUSP00000036964 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. | 0.646 |
| Hook1 | Spatc1l | ENSMUSP00000030306 | ENSMUSP00000009259 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Speriolin-like protein; Belongs to the speriolin family. | 0.431 |
| Hook1 | Sun5 | ENSMUSP00000030306 | ENSMUSP00000028982 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.578 |
| Hook1 | Tsga10 | ENSMUSP00000030306 | ENSMUSP00000048859 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A ; Belongs to the CEP135/TSGA10 family. | 0.509 |
| Pmf1 | Pmfbp1 | ENSMUSP00000062420 | ENSMUSP00000034162 | Polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity). May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton. | 0.675 |