Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Ces1cCarboxylesterase 1C; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant; Belongs to the type-B carboxylesterase/lipase family. (554 aa)    
Predicted Functional Partners:
Rdh7
Retinol dehydrogenase 7; Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities.
   
  
 0.904
Cyp3a11
Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family.
   
 
 0.898
Hrg
Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell [...]
   
 0.896
Apoa5
Apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity).
   
 
 0.893
Ugt2b1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.888
Akr1c6
Estradiol 17 beta-dehydrogenase 5; Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4- androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha- androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively; Belongs to the aldo/keto reductase family.
   
  
 0.881
Cyp3a25
Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
   
 
 0.866
Cyp2c54
Cytochrome P450 2C54; Metabolizes arachidonic acid mainly to 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family.
   
 
 0.864
Agxt
Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes).
   
    0.863
Cyp2c50
Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE).
   
 
 0.856
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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