Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CklfChemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. (152 aa)    
Predicted Functional Partners:
Cmtm6
CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]
   
  
 0.863
Cmtm3
CKLF-like MARVEL transmembrane domain-containing protein 3.
   
  
 0.847
Cmtm4
CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation.
   
  
 0.844
Cmtm5
CKLF-like MARVEL transmembrane domain-containing protein 5; Belongs to the chemokine-like factor family.
      
 0.832
Cmtm8
CKLF-like MARVEL transmembrane domain-containing protein 8.
      
 0.817
Cmtm7
CKLF-like MARVEL transmembrane domain-containing protein 7; Belongs to the chemokine-like factor family.
   
  
 0.814
Cmtm2b
CKLF-like MARVEL transmembrane domain-containing protein 2B; Belongs to the chemokine-like factor family.
      
 0.711
Cmtm2a
CKLF-like MARVEL transmembrane domain-containing protein 2A; Belongs to the chemokine-like factor family.
   
  
 0.657
Pllp
Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).
      
 0.627
Mall
MAL-like protein.
      
 0.585
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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