Oaf protein (mouse) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

Oaf

Out at first protein homolog; Belongs to the OAF family. (282 aa)

Predicted Functional Partners:

Tcn2

0.560

Gm27027

0.530

Dnajc24

0.505

Lemd2

0.486

Mkx

0.432

Klhl14

0.410

Your Current Organism:

Mus musculus

NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dnajc24	Gm27027	ENSMUSP00000099615	ENSMUSP00000138281	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	Predicted gene, 27027.	0.518
Dnajc24	Lemd2	ENSMUSP00000099615	ENSMUSP00000058221	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	0.601
Dnajc24	Oaf	ENSMUSP00000099615	ENSMUSP00000034512	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	Out at first protein homolog; Belongs to the OAF family.	0.505
Gm27027	Dnajc24	ENSMUSP00000138281	ENSMUSP00000099615	Predicted gene, 27027.	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	0.518
Gm27027	Lemd2	ENSMUSP00000138281	ENSMUSP00000058221	Predicted gene, 27027.	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	0.416
Gm27027	Oaf	ENSMUSP00000138281	ENSMUSP00000034512	Predicted gene, 27027.	Out at first protein homolog; Belongs to the OAF family.	0.530
Klhl14	Oaf	ENSMUSP00000113755	ENSMUSP00000034512	Kelch-like protein 14.	Out at first protein homolog; Belongs to the OAF family.	0.410
Lemd2	Dnajc24	ENSMUSP00000058221	ENSMUSP00000099615	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	0.601
Lemd2	Gm27027	ENSMUSP00000058221	ENSMUSP00000138281	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	Predicted gene, 27027.	0.416
Lemd2	Oaf	ENSMUSP00000058221	ENSMUSP00000034512	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	Out at first protein homolog; Belongs to the OAF family.	0.486
Mkx	Oaf	ENSMUSP00000078718	ENSMUSP00000034512	Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.	Out at first protein homolog; Belongs to the OAF family.	0.432
Oaf	Dnajc24	ENSMUSP00000034512	ENSMUSP00000099615	Out at first protein homolog; Belongs to the OAF family.	DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	0.505
Oaf	Gm27027	ENSMUSP00000034512	ENSMUSP00000138281	Out at first protein homolog; Belongs to the OAF family.	Predicted gene, 27027.	0.530
Oaf	Klhl14	ENSMUSP00000034512	ENSMUSP00000113755	Out at first protein homolog; Belongs to the OAF family.	Kelch-like protein 14.	0.410
Oaf	Lemd2	ENSMUSP00000034512	ENSMUSP00000058221	Out at first protein homolog; Belongs to the OAF family.	LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity).	0.486
Oaf	Mkx	ENSMUSP00000034512	ENSMUSP00000078718	Out at first protein homolog; Belongs to the OAF family.	Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation.	0.432
Oaf	Tcn2	ENSMUSP00000034512	ENSMUSP00000105620	Out at first protein homolog; Belongs to the OAF family.	Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.	0.560
Tcn2	Oaf	ENSMUSP00000105620	ENSMUSP00000034512	Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.	Out at first protein homolog; Belongs to the OAF family.	0.560