node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh16a1 | Spg21 | ENSMUSP00000148069 | ENSMUSP00000034955 | Aldehyde dehydrogenase family 16 member A1. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.780 |
Ap5z1 | Nipa1 | ENSMUSP00000041863 | ENSMUSP00000053871 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | 0.484 |
Ap5z1 | Pnpla6 | ENSMUSP00000041863 | ENSMUSP00000146680 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family. | 0.616 |
Ap5z1 | Reep1 | ENSMUSP00000041863 | ENSMUSP00000112662 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity); Belongs to the DP1 family. | 0.514 |
Ap5z1 | Spast | ENSMUSP00000041863 | ENSMUSP00000024869 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination (By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the [...] | 0.494 |
Ap5z1 | Spg11 | ENSMUSP00000041863 | ENSMUSP00000037543 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.972 |
Ap5z1 | Spg20 | ENSMUSP00000041863 | ENSMUSP00000113621 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.513 |
Ap5z1 | Spg21 | ENSMUSP00000041863 | ENSMUSP00000034955 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.593 |
Ap5z1 | Spg7 | ENSMUSP00000041863 | ENSMUSP00000119552 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity); In the C-terminal section; belongs to the peptidase M41 family. | 0.556 |
Ap5z1 | Tecpr2 | ENSMUSP00000041863 | ENSMUSP00000126749 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Tectonin beta-propeller repeat-containing 2. | 0.453 |
Nipa1 | Ap5z1 | ENSMUSP00000053871 | ENSMUSP00000041863 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.484 |
Nipa1 | Pnpla6 | ENSMUSP00000053871 | ENSMUSP00000146680 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family. | 0.528 |
Nipa1 | Reep1 | ENSMUSP00000053871 | ENSMUSP00000112662 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity); Belongs to the DP1 family. | 0.792 |
Nipa1 | Spast | ENSMUSP00000053871 | ENSMUSP00000024869 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination (By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the [...] | 0.718 |
Nipa1 | Spg11 | ENSMUSP00000053871 | ENSMUSP00000037543 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. | 0.557 |
Nipa1 | Spg20 | ENSMUSP00000053871 | ENSMUSP00000113621 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.790 |
Nipa1 | Spg21 | ENSMUSP00000053871 | ENSMUSP00000034955 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.766 |
Nipa1 | Spg7 | ENSMUSP00000053871 | ENSMUSP00000119552 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity); In the C-terminal section; belongs to the peptidase M41 family. | 0.541 |
Nipa1 | Tecpr2 | ENSMUSP00000053871 | ENSMUSP00000126749 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family. | Tectonin beta-propeller repeat-containing 2. | 0.406 |
Pnpla6 | Ap5z1 | ENSMUSP00000146680 | ENSMUSP00000041863 | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family. | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.616 |