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Me1 protein (mouse) - STRING interaction network
"Me1" - Malic enzyme 1, NADP(+)-dependent, cytosolic in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Me1Malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)    
Predicted Functional Partners:
Pcx
Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1179 aa)
   
  0.971
Mdh2
Malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
   
  0.960
Pkm
Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity) (531 aa)
   
  0.958
Mdh1
Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1, NAD (soluble) (334 aa)
   
  0.954
Pklr
Pyruvate kinase PKLR; Plays a key role in glycolysis (574 aa)
   
  0.952
Ldha
Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family (361 aa)
   
  0.945
Fh1
Fumarate hydratase, mitochondrial; Fumarate hydratase 1 (507 aa)
 
  0.944
Pdha1
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle (390 aa)
     
  0.938
Ldhal6b
Lactate dehydrogenase A-like 6B; Belongs to the LDH/MDH superfamily (382 aa)
   
  0.936
Ldhb
Lactate dehydrogenase B; Belongs to the LDH/MDH superfamily. LDH family (334 aa)
   
  0.935
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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